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Non-islet cell tumour-induced hypoglycaemia: a review of the literature including two new cases.非胰岛细胞瘤所致低血糖症：文献综述并附两例新病例
Endocr Relat Cancer. 2007 Dec;14(4):979-93. doi: 10.1677/ERC-07-0161.
2
The mechanism of non-islet cell hypoglycaemia caused by tumour-produced IGF-II.肿瘤产生的胰岛素样生长因子-II导致非胰岛细胞性低血糖症的机制。
Clin Endocrinol (Oxf). 2007 Oct;67(4):637-8. doi: 10.1111/j.1365-2265.2007.02938.x. Epub 2007 Jun 20.
3
The effectiveness of different treatment options for non-islet cell tumour hypoglycaemia.非胰岛细胞瘤低血糖症不同治疗方案的有效性
Clin Endocrinol (Oxf). 2004 Apr;60(4):457-60. doi: 10.1111/j.1365-2265.2004.01989.x.
4
Neoplasms Causing Nonhyperinsulinemic Hypoglycemia.导致非高胰岛素血症性低血糖的肿瘤
Endocr Pathol. 1999 Winter;10(4):291-297. doi: 10.1007/BF02739771.
5
Gene expression and serum levels of insulin-like growth factors (IGFs) and IGF-binding proteins in a case of non-islet cell tumour hypoglycaemia.非胰岛细胞瘤低血糖症病例中胰岛素样生长因子（IGFs）及其结合蛋白的基因表达与血清水平
Growth Horm IGF Res. 1998 Dec;8(6):447-54. doi: 10.1016/s1096-6374(98)80297-9.
6
Hypoglycemia due to an insulin-secreting small-cell carcinoma of the cervix.宫颈胰岛素分泌性小细胞癌所致低血糖症。
N Engl J Med. 1999 Sep 2;341(10):733-6. doi: 10.1056/NEJM199909023411004.
7
Glucocorticoid therapy suppresses abnormal secretion of big IGF-II by non-islet cell tumours inducing hypoglycaemia (NICTH).糖皮质激素疗法可抑制非胰岛细胞瘤（NICTH）诱导低血糖时大IGF-II的异常分泌。
Clin Endocrinol (Oxf). 1998 Oct;49(4):491-8. doi: 10.1046/j.1365-2265.1998.00564.x.
8
The role of insulin-like growth factors and their binding proteins in tumor hypoglycemia.胰岛素样生长因子及其结合蛋白在肿瘤性低血糖症中的作用
Horm Res. 1996;46(4-5):195-201. doi: 10.1159/000185023.
9
Mechanisms of tumor-induced hypoglycemia with intraabdominal hemangiopericytoma.腹腔内血管外皮细胞瘤所致肿瘤性低血糖的机制
J Clin Endocrinol Metab. 1996 Mar;81(3):919-25. doi: 10.1210/jcem.81.3.8772551.
10
Hemangiopericytoma: histopathological pattern or clinicopathologic entity?血管外皮细胞瘤：组织病理学模式还是临床病理实体？
Semin Diagn Pathol. 1995 Aug;12(3):221-32.

低血糖的一种罕见病因。

A rare cause of hypoglycaemia.

作者信息

Dutta Pinaki, Bhansali Anil, Kumar Santosh, Jayaprakash P, Nahar Uma

机构信息

PGIMER, Endocrinology, Sector 12, Chandigarh, 160012, India.

出版信息

BMJ Case Rep. 2009;2009. doi: 10.1136/bcr.04.2009.1789. Epub 2009 Dec 7.

DOI:10.1136/bcr.04.2009.1789
PMID:22148076
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3029287/
Abstract

We describe the case of a 77-year-old man who was admitted with recurrent episodes of altered behaviour. These episodes were related to insulin-like growth factor II (IGF-II) mediated hypoglycaemia. Imaging revealed a large retroperitoneal mass and he underwent debulking surgery uneventfully. Histopathology revealed a solitary fibroma with intense immunostaining positive for CD34 and vimentin, suggesting a mesenchymal origin of the tumour. Later he received chemo/radiotherapy and is on prednisolone with abatement of hypoglycaemic episodes.

摘要

我们描述了一名77岁男性的病例，该患者因行为改变反复发作入院。这些发作与胰岛素样生长因子II（IGF-II）介导的低血糖症有关。影像学检查发现一个巨大的腹膜后肿块，他顺利接受了减瘤手术。组织病理学显示为孤立性纤维瘤，CD34和波形蛋白免疫染色强烈阳性，提示肿瘤起源于间充质。后来他接受了化疗/放疗，目前正在服用泼尼松龙，低血糖发作已减轻。