非胰岛细胞瘤性低血糖症
Non-islet cell tumour hypoglycaemia.
作者信息
Krishnan Leena, Clark John
机构信息
Department of Diabetes and Endocrinology, West Suffolk Hospitals, Bury St. Edmunds, UK.
出版信息
BMJ Case Rep. 2011 Jun 3;2011:bcr0220113914. doi: 10.1136/bcr.02.2011.3914.
Abstract
Non-islet cell tumour hypoglycaemia is a rare paraneoplastic phenomenon where there is spontaneous hypoglycaemia due to secretion of insulin-like growth factor-2 (IGF-2) from large mesenchymal or epithelial tumours. A 67-year-old man presented to the accident and emergency department with a 6-week history of confusion and collapse. Investigations confirmed that he was having recurrent hypoglycaemic attacks. He had been diagnosed with a pelvic solitary fibrous tumour 1 year previously. Further tests demonstrated a high circulating level of IGF-2, which was being secreted by the tumour, confirming a diagnosis of non-islet cell tumour hypoglycaemia. The episodes of hypoglycaemia have resolved following treatment with glucocorticoids. He is currently awaiting radiotherapy.
摘要
非胰岛细胞瘤低血糖症是一种罕见的副肿瘤现象，即大型间充质或上皮肿瘤分泌胰岛素样生长因子-2（IGF-2）导致自发性低血糖。一名67岁男性因6周的意识模糊和晕倒史就诊于急诊部。检查证实他患有复发性低血糖发作。他1年前被诊断出患有盆腔孤立性纤维瘤。进一步检查显示肿瘤分泌的IGF-2循环水平很高，确诊为非胰岛细胞瘤低血糖症。使用糖皮质激素治疗后低血糖发作已得到缓解。他目前正在等待放疗。
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