Ramachandran U, Divekar H M, Grover S K, Srivastava K K
Defence Institute of Physiology and Allied Sciences, Delhi, India.
J Ethnopharmacol. 1990 Jul;29(3):275-81. doi: 10.1016/0378-8741(90)90038-u.
A new animal model for evaluating improvement in physical work performance and endurance in an adverse environment is described. In this model, rats in restraint were exposed to 5 degrees C at 480 mmHg atmospheric pressure. Results were compared to an animal forced to swim in water at 23 degrees C. In both the models, colonic temperature (Tr) of the rats was continually monitored during exposure to adverse environment and during recovery at 32 degrees C and normal atmospheric pressure. The time and pattern for Tr fall to 23 degrees C and its recovery to 37 degrees C were used as measures of endurance. The cold-hypoxia-restraint model was found to provide more precise results compared with the cold-swimming model. Panax ginseng root and Ginkgo biloba leaf extracts were compared for their positive endurance-promoting properties using both models.
本文描述了一种用于评估在恶劣环境下体力工作表现和耐力改善情况的新动物模型。在该模型中，将处于束缚状态的大鼠置于480毫米汞柱大气压、5摄氏度的环境中。将结果与被迫在23摄氏度水中游泳的动物进行比较。在这两种模型中，在大鼠暴露于恶劣环境期间以及在32摄氏度和正常大气压下恢复期间，持续监测其结肠温度（Tr）。Tr降至23摄氏度的时间和模式及其恢复到37摄氏度的情况被用作耐力指标。结果发现，与冷游泳模型相比，冷缺氧束缚模型能提供更精确的结果。使用这两种模型比较了人参根提取物和银杏叶提取物促进耐力的积极特性。
