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剪切应力是心脏瓣膜生物假体耐久性有限的原因吗?

Is cutting stress responsible for the limited durability of heart valve bioprostheses?

作者信息

García Paez J M, Carrera San Martín A, García Sestafe J V, Millán I, Jorge E, Candela I, Castillo-Olivares J L

机构信息

Service of Experimental Surgery, Clínica Puerta de Hierro, Madrid, Spain.

出版信息

J Thorac Cardiovasc Surg. 1990 Oct;100(4):580-6.

PMID:2214834
Abstract

The limited durability of the valve bioprostheses made from calf pericardium is partially due to the calcification of this biomaterial and to mechanical fatigue of the tissue. The object of this study is to determine the harmful effect on the pericardial membrane of cutting caused by the suture thread by showing the different elastic behaviors of the biomaterials employed. This cutting stress is established during the process of molding the valve leaflet, creating a vulnerable point from the very moment of construction, which is an important factor in the limited duration of the bioprosthesis.

摘要

由小牛心包制成的瓣膜生物假体耐久性有限,部分原因是这种生物材料的钙化以及组织的机械疲劳。本研究的目的是通过展示所用生物材料的不同弹性行为,来确定缝线切割对心包膜的有害影响。这种切割应力在瓣膜小叶成型过程中产生,从构建的那一刻起就形成了一个薄弱点,这是生物假体使用寿命有限的一个重要因素。

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引用本文的文献

1
Analysis of shearing stress in the limited durability of bovine pericardium used as a biomaterial.用作生物材料的牛心包有限耐久性中的剪切应力分析。
J Mater Sci Mater Med. 1998 Feb;9(2):77-81. doi: 10.1023/a:1008842914029.
2
Mechanical effects of increases in the load applied in uniaxial and biaxial tensile testing. Part II. Porcine pericardium.单轴和双轴拉伸试验中增加负荷的力学效应。第二部分。猪心包。
J Mater Sci Mater Med. 2002 May;13(5):477-83. doi: 10.1023/a:1014710504963.
3
Sutured calf pericardium: influence of the type and angle of the suture on mechanical behavior.
缝合的小牛心包:缝线类型和角度对力学行为的影响。
J Mater Sci Mater Med. 2003 May;14(5):411-7. doi: 10.1023/a:1023258700845.
4
Porcine pericardial membrane subjected to tensile testing: preliminary study of the process of selecting tissue for use in the construction of cardiac bioprostheses.对猪心包膜进行拉伸测试:用于构建心脏生物假体的组织选择过程的初步研究。
J Mater Sci Mater Med. 2001 May;12(5):425-30. doi: 10.1023/a:1011201104225.
5
The influence of chemical treatment and suture on the elastic behavior of calf pericardium utilized in the construction of cardiac bioprostheses.化学处理和缝合对用于构建心脏生物假体的小牛心包弹性行为的影响。
J Mater Sci Mater Med. 2000 May;11(5):273-7. doi: 10.1023/a:1008901128613.
6
The influence of chemical treatment and suture on the elastic behavior of calf pericardium utilized in the construction of cardiac bioprostheses.化学处理和缝合对用于心脏生物假体构建的小牛心包弹性行为的影响。
J Mater Sci Mater Med. 2000 Jul;11(7):459-64. doi: 10.1023/a:1008996210734.
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