硅二醇催化中的协同氢键作用。
Cooperative hydrogen-bonding effects in silanediol catalysis.
机构信息
Department of Chemistry, University of California, One Shields Avenue, Davis, California 95616, USA.
出版信息
Org Lett. 2012 Jan 6;14(1):186-9. doi: 10.1021/ol202971m. Epub 2011 Dec 7.
The importance of cooperative hydrogen-bonding effects and SiOH-acidification is described for silanediol catalysis. NMR binding, X-ray, and computational studies provide support for a unique dimer resulting from silanediol self-recognition. The significance of this cooperative hydrogen-bonding is demonstrated using novel fluorinated silanediol catalysts for the addition of indoles and N,N-dimethyl-m-anisidine to trans-β-nitrostyrene.
本文描述了氢键协同效应和 SiOH 酸化在硅二醇催化中的重要性。NMR 结合、X 射线和计算研究为硅二醇自识别产生的独特二聚体提供了支持。本文还使用新型氟化硅二醇催化剂，研究了吲哚和 N,N-二甲基间茴香胺与反式-β-硝基苯乙烯的加成反应，进一步证明了这种氢键协同作用的重要性。
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