Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.
J Am Chem Soc. 2012 Jan 11;134(1):134-7. doi: 10.1021/ja2097095. Epub 2011 Dec 19.
The development of a Pd-catalyzed oxidative ortho-C-H borylation with N-arylbenzamides is reported. A modified dibenzylideneacetone (dba) ligand, a weak base, and a strong oxidant are critical for obtaining good yields. The reaction is tolerant of electron-deficient and electron-rich benzamides derived from readily available benzoic acids. The borylated products can be converted to various synthons via diverse transformations.
本文报道了一种钯催化的 N-芳基苯甲酰胺的氧化邻位 C-H 硼化反应。改良的二苄基丙酮（dba）配体、弱碱和强氧化剂对于获得良好产率是至关重要的。该反应对由易得苯甲酸衍生的缺电子和富电子苯甲酰胺具有耐受性。硼化产物可以通过多种转化转化为各种合成子。
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