Faculty of Medicine, Department of Pediatric Hematology, Baskent University, Ankara, Turkey.
Drug Chem Toxicol. 2012 Oct;35(4):463-6. doi: 10.3109/01480545.2011.640684. Epub 2011 Dec 13.
Asparaginase treatment is associated with several adverse effects, including allergy, thromboembolic events, acute pancreatitis, altered liver function, and hyperglycemia. In addition, asparaginase can cause abnormalities in lipid metabolism, predominantly hypercholesterolemia and -triglyceridemia. Herein, we report on the case of a 5-year-old male presenting with acute severe hypertriglyceridemia caused by accidental pegylated asparaginase push during treatment of relapsed acute lymphoblastic leukemia. Hypertriglyceridemia did not occur after appropriate administrations of pegylated asparaginase before and after accidental drug infusions, so we speculate that the rate of pegylated asparaginase administration may have an effect on the serum triglyceride level.
门冬酰胺酶治疗与多种不良反应相关，包括过敏、血栓栓塞事件、急性胰腺炎、肝功能改变和高血糖。此外，门冬酰胺酶还可引起脂代谢异常，主要为高胆固醇血症和高三酰甘油血症。在此，我们报告了一例 5 岁男性病例，在复发的急性淋巴细胞白血病治疗过程中，由于意外推注聚乙二醇化门冬酰胺酶，导致急性重度高三酰甘油血症。在意外推注药物前后，给予合适剂量的聚乙二醇化门冬酰胺酶后并未发生三酰甘油升高，因此我们推测门冬酰胺酶给药速度可能会对血清三酰甘油水平产生影响。
