胸腺中自身反应性 T 细胞的选择。
Selection of self-reactive T cells in the thymus.
机构信息
Center for Immunology and Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota 55455, USA.
出版信息
Annu Rev Immunol. 2012;30:95-114. doi: 10.1146/annurev-immunol-020711-075035. Epub 2011 Dec 5.
Abstract
On the whole, the healthy adaptive immune system is responsive to foreign antigens and tolerant to self. However, many individual lymphocytes have, and even require, substantial self-reactivity for their particular functions in immunity. In this review, we discuss several populations of lymphocytes that are thought to experience agonist stimulation through the T cell receptor during selection: nTreg cells, iNKT cells, nIELs, and nTh17s. We discuss the nature of this self-reactivity, how it compares with conventional T cells, and why it is important for overall immune health. We also outline molecular pathways unique to each lineage and consider possible commonalities to their development and survival.
摘要
总的来说，健康的适应性免疫系统对异源抗原有反应性，对自身有耐受性。然而，许多单个淋巴细胞具有甚至需要其在免疫中的特定功能的大量自身反应性。在这篇综述中，我们讨论了一些被认为在选择过程中通过 T 细胞受体经历激动剂刺激的淋巴细胞群体：nTreg 细胞、iNKT 细胞、nIELs 和 nTh17s。我们讨论了这种自身反应性的性质，它与传统 T 细胞的比较，以及为什么它对整体免疫健康很重要。我们还概述了每个谱系特有的分子途径，并考虑了它们的发展和存活的可能共性。
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