Klein Ludger, Hinterberger Maria, Wirnsberger Gerald, Kyewski Bruno
Institute for Immunology, Ludwig-Maximilians University, Goethestrasse 31, 80336 Munich, Germany.
Nat Rev Immunol. 2009 Dec;9(12):833-44. doi: 10.1038/nri2669.
Understanding how thymic selection imparts self-peptide-MHC complex restriction and a high degree of self tolerance on the T cell repertoire requires a detailed description of the parameters that shape the MHC ligand repertoire of distinct thymic antigen-presenting cells and of how these cells communicate with T cells. Several recent discoveries pertaining to cortex-specific pathways of antigen processing, the heterogeneity of thymic dendritic cells and the intercellular transfer of self antigens have uncovered surprising and unique aspects of antigen presentation in the thymic microenvironment. Here, we discuss these new findings in the context of how individual thymic stromal cell types support T cell selection in a cooperative rather than a redundant manner.
要理解胸腺选择如何赋予T细胞库自我肽-MHC复合物限制性以及高度的自我耐受性，需要详细描述塑造不同胸腺抗原呈递细胞的MHC配体库的参数，以及这些细胞如何与T细胞进行通信。最近关于皮质特异性抗原加工途径、胸腺树突状细胞的异质性以及自身抗原的细胞间转移的几项发现，揭示了胸腺微环境中抗原呈递令人惊讶和独特的方面。在这里，我们将在个体胸腺基质细胞类型如何以协同而非冗余的方式支持T细胞选择的背景下讨论这些新发现。
