dos Santos Lúcia de Fátima Cavalcanti, Carvalho Alessandra de Albuquerque Tavares, Leão Jair Carneiro, Cruz Perez Danyel Elias da, Castro Jurema Freire Lisboa de
Department of Clinical and Preventive Dentistry, Oral Medicine Unit, Federal University of Pernambuco, Recife/PE, Brazil.
Photomed Laser Surg. 2011 Dec;29(12):793-6. doi: 10.1089/pho.2011.3016.
The aim of this study was evaluate the effect of low-level laser therapy (LLLT) in the treatment of burning mouth syndrome (BMS) patients.
BMS is a clinical condition characterized by a burning sensation in a morphologically normal oral mucosa, without association with systemic disorders.
Ten patients with oral burning sensation were included in the study. After careful evaluation of medical history and oral examination, the diagnosis of BMS was established. All patients were submitted to one weekly session of LLLT for 10 weeks. A continuous wavelength of 660 nm, power 40 mW, 20 J/cm(2), 0.8 J/point, with each point irradiated for 10 sec. In all sessions the burning intensity was evaluated with a 10-cm visual analogue scale (VAS), with 0 indicating no symptoms and 10 indicating the worst burning possible. The burning intensity evaluation by VAS was performed immediately before (VAS baseline) and immediately after each LLLT session. The nonparametric Wilcoxon test was used for statistical analysis, considering significance of 5%.
All patients reported improvement in all sessions, with reduction in VAS scores by up to 58% in the tenth session. When only the VAS baseline of the first session was compared with the other sessions, there was a statistically significant reduction in VAS scores in the fourth (p=0.03), fifth (p=0.03), sixth (p=0.009), seventh (p=0.003), eighth, ninth, and tenth (all p=0.002) sessions.
LLLT may be an alternative treatment for the relief of oral burning in patients with BMS.
本研究旨在评估低强度激光疗法（LLLT）对灼口综合征（BMS）患者的治疗效果。
BMS是一种临床病症，其特征为形态正常的口腔黏膜出现烧灼感，且与全身疾病无关。
本研究纳入了10名有口腔烧灼感的患者。在仔细评估病史和口腔检查后，确诊为BMS。所有患者每周接受一次LLLT治疗，共10周。连续波长为660nm，功率40mW，20J/cm²，0.8J/点，每点照射10秒。在所有疗程中，使用10厘米视觉模拟量表（VAS）评估烧灼强度，0表示无症状，10表示可能的最严重烧灼。在每次LLLT疗程前（VAS基线）和疗程后立即通过VAS进行烧灼强度评估。采用非参数Wilcoxon检验进行统计分析，显著性水平为5%。
所有患者在所有疗程中均报告症状改善，在第十个疗程中VAS评分降低高达58%。仅将第一个疗程的VAS基线与其他疗程进行比较时，在第四个（p=0.03）、第五个（p=0.03）、第六个（p=0.009）、第七个（p=0.003）、第八个、第九个和第十个（均p=0.002）疗程中，VAS评分有统计学显著降低。
LLLT可能是缓解BMS患者口腔烧灼感的一种替代治疗方法。
