Department of Paediatric Neurology, Leeds General Infirmary, Leeds, UK.
Dev Med Child Neurol. 2012 Apr;54(4):376-9. doi: 10.1111/j.1469-8749.2011.04167.x. Epub 2011 Dec 8.
We report the cases of three children, one male and two females, with a diagnosis of early infantile Krabbe disease demonstrating intracranial calcification on computed tomography (CT). The pattern of calcification was similar in all individuals and involved the internal capsule and cerebral white matter. The presence of calcification caused some diagnostic confusion in what was otherwise a typical clinical and radiological presentation. This finding is not new and has previously been described in publications from the 1980s and 1990s reporting the CT and magnetic resonance imaging appearances of Krabbe disease. With increasing use of magnetic resonance as the first imaging modality for investigation of neurological disorders, characteristic CT appearances may be forgotten. This report serves as a reminder that Krabbe disease should be included in the differential diagnosis of disorders causing intracranial calcification.
我们报告了三例婴儿型克雅氏病患儿的病例，1 男 2 女，均在计算机断层扫描（CT）上显示颅内钙化。所有个体的钙化模式均相似，涉及内囊和脑白质。钙化的存在在其他方面典型的临床和放射学表现中引起了一些诊断上的混淆。这一发现并不新鲜，以前在 20 世纪 80 年代和 90 年代的出版物中已有描述，这些出版物报告了克雅氏病的 CT 和磁共振成像表现。随着磁共振成像作为神经疾病检查的首选成像方式的应用越来越多，特征性 CT 表现可能被遗忘。本报告提醒人们，克雅氏病应纳入引起颅内钙化的疾病的鉴别诊断中。
