脊髓刺激对链脲佐菌素诱导糖尿病大鼠外周血液循环的影响。
Effects of spinal cord stimulation on peripheral blood circulation in rats with streptozotocin-induced diabetes.
机构信息
Department of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA; Department of Pharmacology and Pharmacotherapy, The Danish University of Pharmaceutical Sciences, Copenhagen, Denmark; and Department of Neurosurgery, Karolinska University Hospital, Stockholm, Sweden.
出版信息
Neuromodulation. 2007 Jul;10(3):216-23. doi: 10.1111/j.1525-1403.2007.00111.x.
Objective. The aim of this study was to investigate the effects of spinal cord stimulation (SCS) on peripheral circulation in rats with streptozotocin (STZ)-induced diabetes. Materials and Methods. Four weeks after streptozotocin or vehicle was injected (i.p.) in male Sprague-Dawley rats, SCS-induced vasodilation was examined. Results. Plasma glucose concentration was significantly higher in diabetic rats than in the control animals. Motor threshold (MT) was significantly higher in diabetic rats than in control rats. SCS-induced vasodilation was attenuated at 90% of the MT, but not at 30% and 60% of MT in diabetic rats when compared to control rats (p < 0.001, N = 13). Furthermore, increasing SCS from 30% to 90% of MT typically produced a progressive increase in blood flow in control rats but not in diabetic rats (p < 0.01, N = 13). Conclusion. This study suggested that SCS-induced vasodilation improves peripheral blood flow, although the pathways were partially impaired in the diabetic condition.
目的。本研究旨在探讨脊髓刺激（SCS）对链脲佐菌素（STZ）诱导糖尿病大鼠外周循环的影响。
材料和方法。雄性 Sprague-Dawley 大鼠腹腔注射链脲佐菌素或载体 4 周后，检测 SCS 诱导的血管扩张。
结果。糖尿病大鼠的血糖浓度明显高于对照组。糖尿病大鼠的运动阈值（MT）明显高于对照组。与对照组相比，当 SCS 刺激达到 MT 的 90%时，糖尿病大鼠的 SCS 诱导血管扩张减弱，但当 SCS 刺激达到 MT 的 30%和 60%时，两组间没有差异（p<0.001，N=13）。此外，在对照组中，SCS 从 MT 的 30%增加到 90%通常会导致血流量逐渐增加，但在糖尿病大鼠中则不会（p<0.01，N=13）。
结论。本研究表明，SCS 诱导的血管扩张可改善外周血流量，尽管在糖尿病状态下部分通路受损。
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