Zhang Ying, Zhang Huifeng, Wang Kaizhong, Liu Xiangyan, Li Zhonghai
Department of Orthopedics, First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning Province, China.
Key Laboratory of Molecular Mechanism for Repair and Remodeling of Orthopedic Diseases, Dalian, Liaoning Province, China.
Pain Ther. 2025 Apr;14(2):589-616. doi: 10.1007/s40122-025-00710-0. Epub 2025 Feb 5.
Chronic pain in the diabetic foot (DF) is a common complication of diabetes, bringing a significant burden to patients, their families, and even society. There is no very effective treatment for it, traditional treatments such as medication, lumbar sympathetic nerve block, and alternative therapies are often not very effective and have more adverse effects. The emergence of neuromodulation technology has brought new hope for the treatment of DF, among which spinal cord stimulation (SCS) is a hotspot in current research and has achieved remarkable efficacy in the study of DF treatment by blocking pain signaling and improving circulation and other mechanisms. This article reviews the SCS technique and clinical trails of SCS for chronic DF pain, and describes the prospects and current challenges of SCS.
糖尿病足（DF）慢性疼痛是糖尿病的常见并发症，给患者及其家庭乃至社会带来了沉重负担。目前尚无非常有效的治疗方法，药物治疗、腰交感神经阻滞等传统治疗方法以及替代疗法往往效果不佳且不良反应较多。神经调节技术的出现为DF治疗带来了新希望，其中脊髓刺激（SCS）是当前研究的热点，通过阻断疼痛信号和改善血液循环等机制，在DF治疗研究中取得了显著疗效。本文综述了SCS技术以及SCS治疗DF慢性疼痛的临床试验，并阐述了SCS的前景和当前面临的挑战。
