Chang C L, Lin S S, Tsai Y C, Lee K C, Lee C Y, Kao C H, Cheng J T
Department of Anesthesiology, National Cheng-Kung University, Medical College and Hospital.
Ma Zui Xue Za Zhi. 1990 Jun;28(2):113-9.
Plasma levels of neuropeptide Y (NPY) and catecholamines were investigated during spinal anesthesia. Ten ASA physical status I-II patients were studied after obtaining institutional approval and informed contents. All patients were free from endocrine and metabolic disease underwent elective low risk operation. No premedication was given before operation. Spinal anesthesia was performed on lateral position from L3-4 interspace with 15 mg tetracaine without added epinephrine. The analgesic level was about at T6 dermatone. Blood samples were obtained from radial artery catheter, 15 minutes before spinal anesthesia and 5', 15', 30', 60', 120', during operative period and 30' after operation in postanesthesia recovery room. The results showed that there were significant elevation in plasma level of NPY during spinal anesthesia compared with the level before anesthesia. However, no statistically significant changes of plasma catecholamines were found.
在脊髓麻醉期间对神经肽Y（NPY）和儿茶酚胺的血浆水平进行了研究。在获得机构批准并告知相关内容后，对10例美国麻醉医师协会（ASA）身体状况为I-II级的患者进行了研究。所有患者均无内分泌和代谢疾病，接受择期低风险手术。术前未给予术前用药。患者取侧卧位，于L3-4椎间隙行脊髓麻醉，使用15mg丁卡因，未加肾上腺素。镇痛平面约在T6皮节。在脊髓麻醉前15分钟以及手术期间的5分钟、15分钟、30分钟、60分钟、120分钟以及麻醉恢复室术后30分钟，从桡动脉导管采集血样。结果显示，与麻醉前水平相比，脊髓麻醉期间血浆NPY水平显著升高。然而，血浆儿茶酚胺未发现有统计学意义的变化。
