Chang C L, Lin S S, Tzeng C C, Yeh F C, Lai Y Y, Hwang S J, Leung P O, Su H P, Cheng J T
Department of Anesthesiology, National Cheng-Kung University Medical College and Hospital.
Ma Zui Xue Za Zhi. 1990 Sep;28(3):265-71.
Twelve ASA physical status I-II patients were studied after obtaining institutional approval and informed contents. All patients were free from endocrine and metabolic disease undergoing elective low risk operation. Pethidine 1 mg/kg i.m. and benzodiazepine 0.01 mg/kg p.o. were given as premedication one hour before anesthesia. Anesthesia was induced with thiopental 4 mg/kg and succinylcholine 1.5 mg/kg for tracheal intubation. Anesthesia was maintained with 2% isoflurane and 50% N2O in oxygen. Ventilation was controlled and adjusted to maintain an end-tidal CO2 concentration of 25-35 torr. Atracurium 0.4 mg/kg was given as muscle relaxant. Blood samples were obtained from radial arterial catheter, 15 minutes before induction of anesthesia and 5 min after anesthesia, 15 min, 30 min, 60 min during operation and 30 min after operation in postanesthesia recovery room. The results showed that there were no statistically significant changes in plasma levels of NPY and catecholamines during operation underwent isoflurane anesthetic technique. This result indicates that isoflurane anesthesia can block the plasma NPY as well as catecholamines during surgical stress.
在获得机构批准并告知相关内容后，对12例ASA身体状况为I-II级的患者进行了研究。所有患者均无内分泌和代谢疾病，接受择期低风险手术。麻醉前1小时，肌肉注射哌替啶1mg/kg和口服苯二氮䓬0.01mg/kg作为术前用药。用硫喷妥钠4mg/kg和琥珀酰胆碱1.5mg/kg诱导麻醉以进行气管插管。用2%异氟烷和50%氧化亚氮与氧气混合维持麻醉。控制并调整通气以维持呼气末二氧化碳浓度在25-35托。给予阿曲库铵0.4mg/kg作为肌肉松弛剂。在麻醉诱导前15分钟、麻醉后5分钟、手术期间的15分钟、30分钟、60分钟以及麻醉后恢复室手术后30分钟，从桡动脉导管采集血样。结果表明，在采用异氟烷麻醉技术的手术过程中，血浆神经肽Y（NPY）和儿茶酚胺水平无统计学显著变化。该结果表明，异氟烷麻醉可在手术应激期间阻断血浆NPY以及儿茶酚胺。
