Department of Neurological Surgery, University of Washington School of Medicine, Seattle, Washington.
Neuromodulation. 2000 Apr;3(2):75-81. doi: 10.1046/j.1525-1403.2000.00075.x.
Objective. To determine the long-term relief of spasticity and complication rates in patients who underwent placement of a programmable intrathecal baclofen pump for treatment of medically intractable spasticity of spine or brain etiology. Methods. Sixty-two consecutive adult patients who underwent placement of a programmable pump were retrospectively reviewed. Results. Spasticity was clinically and statistically significantly decreased in all patients. Catheter-related kinks, breaks, dislodgments, and disconnections were the most common complications followed by drug-related effects, infections, and wound complications. Conclusions. Intrathecal baclofen is a very effective strategy for the relief of medically intractable spasticity of spine or brain etiology. Even though 36% of patients have required revisions, no patient has experienced any long-term morbidity. Patients and their primary care givers have been pleased with the long-term effects of this therapy upon quality of life.
目的。确定接受可编程鞘内巴氯芬泵植入治疗脊柱或脑病因所致医学上难以治疗的痉挛的患者的痉挛长期缓解率和并发症发生率。
方法。回顾性分析了 62 例连续接受可编程泵植入的成年患者。
结果。所有患者的痉挛均得到临床和统计学上的显著改善。导管相关的扭结、断裂、移位和断开是最常见的并发症，其次是药物相关的影响、感染和伤口并发症。
结论。鞘内巴氯芬是治疗脊柱或脑病因所致医学上难以治疗的痉挛的一种非常有效的策略。尽管 36%的患者需要进行修订，但没有患者出现任何长期的发病率。患者及其主要照顾者对这种治疗方法对生活质量的长期影响感到满意。
