Graduate Institute and School of Physical Therapy, College of Medicine, National Taiwan University, Taiwan; Department of Physical Medicine and Rehabilitation, National Taiwan University Hospital, Taiwan; Center of Physical Therapy, National Taiwan University Hospital, Taiwan; and Department of Obstetric and Gynecology, Department and Graduate institute of Forensic Medicine, College of Medicine, National Taiwan University, Taiwan.
Neuromodulation. 2009 Oct;12(4):302-9. doi: 10.1111/j.1525-1403.2009.00226.x. Epub 2009 Aug 20.
Objectives. Dysmenorrhea is a disturbing problem among women of childbearing age. The purpose of this study is to investigate the effect of high-frequency transcutaneous electrical nerve stimulation (TENS) on primary dysmenorrhea and to compare the placebo effect by sham TENS in a randomized controlled study. Materials and Methods. Twenty-two women participated in the two-month experiment by using TENS or sham TENS in a random order for their dysmenorrhea. Outcome measures included self-reported pain intensity, symptom and function questionnaire related to dysmenorrhea, quality of life, satisfaction after TENS application, and other pain management agents adapted by the participants. Two-way repeated measures analysis of variance (two-way ANOVA) was conducted to compare pain intensity between pre-post values and groups (TENS vs. placebo). One-way repeated measures analysis of variance (one-way ANOVA) was conducted to compare scores from questionnaire of symptoms and quality of life at baseline, and after placebo or TENS stimulation. Results. Pain intensity in TENS is significantly decreased than in the placebo group (p= 0.018). The decrease of pain intensity after TENS and placebo TENS were both significant, with p < 0.00005 and p < 0.00005 respectively. Furthermore, TENS significantly changed the degree of autonomic symptoms (p= 0.048); but not after placebo TENS. Conclusion. This result supports that women in our country who suffer from primary dysmenorrhea could benefit by using TENS, which is consistent with the previous studies. In addition to pain-relieving effects, relief of the autonomic symptoms associated with dysmenorrhea also indicated that the mechanism of TENS might be different from the placebo effect of the sham TENS stimulation. These findings indicate the immediate effects of TENS in women with primary dysmenorrheal.
目的。痛经是育龄妇女的一个困扰问题。本研究的目的是调查高频经皮神经电刺激(TENS)对原发性痛经的影响,并通过随机对照研究比较假 TENS 的安慰剂效应。
材料和方法。22 名女性参与了为期两个月的实验,她们按照随机顺序使用 TENS 或假 TENS 治疗痛经。结果测量包括自我报告的疼痛强度、与痛经相关的症状和功能问卷、生活质量、TENS 应用后的满意度以及参与者采用的其他疼痛管理药物。采用双向重复测量方差分析(双向 ANOVA)比较 TENS 与安慰剂组之间的疼痛强度在治疗前后的差异。采用单向重复测量方差分析(单向 ANOVA)比较基线时和假 TENS 或 TENS 刺激后的症状和生活质量问卷评分。
结果。TENS 组的疼痛强度明显低于安慰剂组(p=0.018)。TENS 和假 TENS 后疼痛强度的降低均具有统计学意义,分别为 p<0.00005 和 p<0.00005。此外,TENS 显著改变了自主症状的程度(p=0.048);但假 TENS 后没有改变。
结论。这个结果支持我国原发性痛经的女性可以从 TENS 中受益,这与之前的研究一致。除了缓解疼痛的效果外,缓解与痛经相关的自主症状也表明 TENS 的机制可能与假 TENS 刺激的安慰剂效应不同。这些发现表明 TENS 在原发性痛经妇女中的即时效果。