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细胞分化:中体残留物——垃圾还是命运因子?

Cell differentiation: midbody remnants - junk or fate factors?

机构信息

Department of Biochemistry, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, N-0310 Oslo, Norway.

出版信息

Curr Biol. 2011 Dec 6;21(23):R958-60. doi: 10.1016/j.cub.2011.10.035. Epub 2011 Dec 5.

DOI:10.1016/j.cub.2011.10.035
PMID:22153165
Abstract

The midbody is an electron-dense structure that forms between two dividing daughter cells, and a midbody remnant is left after completion of cell separation. This structure has been regarded as a piece of cellular debris, but two recent papers suggest an unexpected function for the midbody remnant in promoting an undifferentiated cellular phenotype.

摘要

中体是在两个分裂的子细胞之间形成的电子致密结构,细胞分离完成后会留下一个中体残余物。这个结构一直被认为是细胞碎片的一部分,但最近的两篇论文表明中体残余物在促进未分化的细胞表型方面具有意想不到的功能。

相似文献

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Cell differentiation: midbody remnants - junk or fate factors?细胞分化:中体残留物——垃圾还是命运因子?
Curr Biol. 2011 Dec 6;21(23):R958-60. doi: 10.1016/j.cub.2011.10.035. Epub 2011 Dec 5.
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Universal patterns of stem cell fate in cycling adult tissues.成体组织中干细胞命运的普遍模式。
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A simple model for the fate of the cytokinesis midbody remnant: implications for remnant degradation by autophagy.细胞分裂中体残余物命运的简单模型:对残余物通过自噬降解的影响。
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Drosophila neuroblast asymmetric cell division: recent advances and implications for stem cell biology.果蝇神经母细胞不对称细胞分裂:干细胞生物学的最新进展及意义
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Miranda directs Prospero to a daughter cell during Drosophila asymmetric divisions.在果蝇不对称分裂过程中,米兰达将普罗米修斯引导至一个子细胞。
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Timing cell-fate determination during asymmetric cell divisions.在不对称细胞分裂过程中确定细胞命运的时机。
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The ups and downs of neural progenitors: Cep120 and TACCs control interkinetic nuclear migration.神经祖细胞的起伏:Cep120和TACC蛋白控制核内运动。
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The midbody and midbody remnant: from cellular debris to signaling organelle with diagnostic and therapeutic potential.中间体及中间体残余物:从细胞碎片到具有诊断和治疗潜力的信号细胞器
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The mammalian midbody and midbody remnant are assembly sites for RNA and localized translation.哺乳动物的中体和中体残留物是 RNA 和局部翻译的组装位点。
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Branched germline cysts and female-specific cyst fragmentation facilitate oocyte determination in mice.
分支性生殖细胞囊和雌性特异性囊泡碎裂有助于小鼠卵母细胞的决定。
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ER stress: Autophagy induction, inhibition and selection.内质网应激:自噬的诱导、抑制与选择
Autophagy. 2015 Nov 2;11(11):1956-1977. doi: 10.1080/15548627.2015.1091141.
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Binding of Kif23-iso1/CHO1 to 14-3-3 is regulated by sequential phosphorylations at two LATS kinase consensus sites.Kif23-iso1/CHO1与14-3-3的结合受两个LATS激酶共有位点的顺序磷酸化调节。
PLoS One. 2015 Feb 6;10(2):e0117857. doi: 10.1371/journal.pone.0117857. eCollection 2015.
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An integrated overview of spatiotemporal organization and regulation in mitosis in terms of the proteins in the functional supercomplexes.从功能超复合物中的蛋白质角度对有丝分裂中的时空组织与调控进行综合概述。
Front Microbiol. 2014 Oct 29;5:573. doi: 10.3389/fmicb.2014.00573. eCollection 2014.
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The vertebrate-specific Kinesin-6, Kif20b, is required for normal cytokinesis of polarized cortical stem cells and cerebral cortex size.脊椎动物特异性的驱动蛋白-6(Kinesin-6),Kif20b,对于极化皮质干细胞的正常胞质分裂和大脑皮层大小是必需的。
Development. 2013 Dec;140(23):4672-82. doi: 10.1242/dev.093286. Epub 2013 Oct 30.
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Stereotyped distribution of midbody remnants in early C. elegans embryos requires cell death genes and is dispensable for development.早期秀丽隐杆线虫胚胎中体残余物的刻板分布需要细胞死亡基因,且对发育并非必需。
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Apoptotic regulators promote cytokinetic midbody degradation in C. elegans.凋亡调节因子促进秀丽隐杆线虫细胞分裂末期中体的降解。
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