Department of Ecology, University of Barcelona, Av. Diagonal, 645, 08028 Barcelona, Spain.
Ecotoxicol Environ Saf. 2012 Apr;78:110-5. doi: 10.1016/j.ecoenv.2011.11.004. Epub 2011 Dec 5.
New analytical methods are available for detecting novel xenobiotic compounds in freshwater systems. Pharmaceuticals are suspected of having effects on freshwater biota at very low concentrations, although the nature of these effects remains unclear. Previous data from the Llobregat River revealed a positive statistical relationship between the biomass of benthic macroinvertebrates and the presence of certain non-steroidal anti-inflammatory drugs (NSAIDs) and beta-blockers. Here, experiments were conducted with the midge Chironomus riparius and the freshwater snail Physella (Costatella) acuta in sediments and water, respectively. The sediments and water were treated with the pharmaceuticals propranolol and indomethacin, with the aims of assaying the effects of these compounds on the organisms and testing the statistical relationships observed in field. The variables measured were survival; C. riparius biomass; and the carbon/nitrogen ratio, lipid content and fertility of freshwater snails. Indomethacin in treated sediments induced an increase in C. riparius biomass, whereas propranolol inhibited growth, albeit at marginal statistical significance. By contrast, indomethacin in water had no effect on any of the parameters measured in P. acuta.
新的分析方法可用于检测淡水系统中的新型外来化合物。尽管这些影响的性质尚不清楚，但人们怀疑药品会以非常低的浓度对淡水生物群产生影响。来自 Llobregat 河的先前数据显示，底栖大型无脊椎动物的生物量与某些非甾体抗炎药（NSAIDs）和β受体阻滞剂的存在之间存在正统计学关系。在这里，分别在沉积物中和水中用摇蚊 Chironomus riparius 和淡水蜗牛 Physella acuta 进行了实验。用药物普萘洛尔和吲哚美辛处理沉积物和水，目的是测定这些化合物对生物体的影响，并检验在野外观察到的统计关系。测量的变量包括生存；C. riparius 生物量；以及淡水蜗牛的碳/氮比、脂质含量和繁殖力。处理过的沉积物中的吲哚美辛诱导 C. riparius 生物量增加，而普萘洛尔尽管在统计学上意义不大，但抑制了生长。相比之下，水中的吲哚美辛对 P. acuta 测量的任何参数都没有影响。
