Department of Pathology, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands.
Hum Pathol. 2012 May;43(5):764-8. doi: 10.1016/j.humpath.2011.08.004. Epub 2011 Dec 7.
Soft tissue myoepithelial tumors, a recently defined entity, include benign and malignant lesions showing a considerable morphological and immunohistochemical heterogeneity. EWSR1 rearrangements are well recognized in this tumor type, and some of the partner genes have been identified. Herein we describe a soft tissue myoepithelioma arising in the pelvis with an EWSR1-ATF1 fusion, therefore extending the spectrum of partner genes of EWSR1. In addition, this case indicates that there are overlapping genetic features of myoepithelial tumors, clear cell sarcoma, angiomatoid fibrous histiocytoma, and hyalinizing clear-cell carcinoma of the salivary gland.
软组织肌上皮肿瘤是一种新近定义的实体，包括具有相当大的形态学和免疫组织化学异质性的良性和恶性病变。EWSR1 重排在这种肿瘤类型中得到了很好的认识，并且已经确定了一些伙伴基因。本文描述了一例发生在骨盆的软组织肌上皮瘤，具有 EWSR1-ATF1 融合，因此扩展了 EWSR1 的伙伴基因谱。此外，该病例表明肌上皮肿瘤、透明细胞肉瘤、血管瘤样纤维组织细胞瘤和唾液腺透明细胞癌具有重叠的遗传特征。
