David H. Koch Institute for Integrative Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Int J Parasitol. 2012 Jan;42(1):21-32. doi: 10.1016/j.ijpara.2011.11.007. Epub 2011 Dec 4.
Some apicomplexan parasites have evolved distinct protein kinase families to modulate host cell structure and function. Toxoplasma gondii rhoptry protein kinases and pseudokinases are involved in virulence and modulation of host cell signalling. The proteome of Plasmodium falciparum contains a family of putative kinases called FIKKs, some of which are exported to the host red blood cell and might play a role in erythrocyte remodelling. In this review we will discuss kinases known to be critical for host cell invasion, intracellular growth and egress, focusing on (i) calcium-dependent protein kinases and (ii) the secreted kinases that are unique to Toxoplasma (rhoptry protein kinases and pseudokinases) and Plasmodium (FIKKs).
一些顶复门寄生虫已经进化出独特的蛋白激酶家族来调节宿主细胞的结构和功能。刚地弓形虫的泡颈蛋白激酶和拟激酶参与了毒力和宿主细胞信号转导的调节。疟原虫的蛋白质组包含一个称为 FIKKs 的假定激酶家族，其中一些被输出到宿主红细胞，并可能在红细胞重塑中发挥作用。在这篇综述中，我们将讨论已知对宿主细胞入侵、细胞内生长和逸出至关重要的激酶，重点讨论（i）钙依赖性蛋白激酶和（ii）刚地弓形虫（泡颈蛋白激酶和拟激酶）和疟原虫（FIKKs）所特有的分泌激酶。
