St Mary's Hospital Medical School, Praed Street, London W2 1NY, UK.
J Psychopharmacol. 1989 Jan;3(2):47-53. doi: 10.1177/026988118900300201.
Antidepressants are used for long periods of time and until recently there were no formal requirements for establishing efficacy in the maintenance phase or the prophylactic phase of the treatment of depression. The CPMP guidelines advise regulatory authorities in the EEC to consider the efficacy of antidepressants in the medium and the long term separately from efficacy in the treatment of the acute episode. This paper reviews the efficacy of antidepressants in continuation treatment and prophylactic treatment of unipolar depression. Prophylactic studies are difficult and time consuming and it is important to adopt adequate trial methodology. The minimum criteria for the demonstration of prophylactic efficacy are presented.
抗抑郁药需要长期使用，直到最近，在确立维持治疗或预防治疗抑郁症的疗效方面还没有正式的要求。人用药品注册技术要求国际协调会议（CPMP）的指南建议 EEC 的监管机构将抗抑郁药在中期和长期的疗效与急性发作的疗效分开考虑。本文综述了抗抑郁药在单相抑郁症的延续治疗和预防治疗中的疗效。预防研究困难且耗时，采用适当的试验方法很重要。本文提出了预防疗效的最低标准。
