Rosenberg R S, Zepelin H, Rechtschaffen A
J Gerontol. 1979 Jul;34(4):525-32. doi: 10.1093/geronj/34.4.525.
Five young rats, age 152--175 days, and six old rats, age 782--801 days, all of the F-344 strain, were compared by electronic methods for amplitude of slow wave activity during sleep and for other sleep parameters. Unlike humans, who show a pronounced loss of slow wave activity with advanced age, no significant difference in delta activity could be detected between young and old rats. Several hypotheses about the species difference were reviewed. Young and old rats, however, did show several differences in other sleep parameters which parallel those observed in humans. These age-related changes were a moderate decrease in the percent of total sleep time spent in paradoxical sleep, a decrease in the length of sleep bouts, an increase in the number of sleep bouts, and a decrease in the amplitude of the diurnal rhythm of sleep.
对5只年龄在152至175天的年轻F-344品系大鼠和6只年龄在782至801天的老年F-344品系大鼠，采用电子方法比较了睡眠期间慢波活动的幅度以及其他睡眠参数。与人类不同，人类随着年龄增长慢波活动会明显减少，而在年轻和老年大鼠之间未检测到δ活动有显著差异。对有关物种差异的几种假说进行了综述。然而，年轻和老年大鼠在其他睡眠参数上确实表现出一些与人类观察到的情况相似的差异。这些与年龄相关的变化包括异相睡眠占总睡眠时间的百分比适度降低、睡眠周期长度缩短、睡眠周期数量增加以及睡眠昼夜节律幅度减小。
