解析 HIV 特异性 CD8+ T 细胞应答中的异质性。
Deconvolving heterogeneity in the CD8+ T-cell response to HIV.
机构信息
Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA.
出版信息
Curr Opin HIV AIDS. 2012 Jan;7(1):38-43. doi: 10.1097/COH.0b013e32834dde1c.
PURPOSE OF REVIEW
This review will discuss the use of systems biology approaches to dissect the heterogeneity of the HIV-specific CD8+ T-cell response.
RECENT FINDINGS
New experimental approaches have allowed complex phenotypes of individual cells present in the human antigen-specific CD8+ T-cell response to be characterized. Genome-wide measurements of gene expression in antigen-specific T cells have created broad molecular phenotypes of the T-cell response to HIV. Pattern recognition algorithms to discover new subclasses of samples in microarray datasets are becoming increasingly sophisticated. Together, these advances now allow the heterogeneity of the T-cell response to HIV to be unraveled.
SUMMARY
The phenotype of antigen-specific T cells responding to pathogens like HIV in humans is seen as much 'noisier' than in animal models of infection. However, applying new systems biology tools may provide an opportunity to identify the sources of this 'noise' as novel, biologically distinct subclasses of the CD8+ T-cell response to HIV.
目的综述
本文综述了系统生物学方法在剖析 HIV 特异性 CD8+ T 细胞反应异质性中的应用。
最近的发现
新的实验方法能够对人源 HIV 特异性 CD8+ T 细胞反应中存在的单个细胞的复杂表型进行分析。对 HIV 特异性 T 细胞的全基因组基因表达测量，创建了 HIV 特异性 T 细胞反应的广泛分子表型。用于发现微阵列数据集中新样本子类的模式识别算法变得越来越复杂。这些进展使得 HIV 特异性 T 细胞反应的异质性得以揭示。
总结
与感染的动物模型相比，人类针对 HIV 等病原体的抗原特异性 T 细胞的表型显得更加“嘈杂”。然而，应用新的系统生物学工具可能为识别这种“噪声”的来源提供机会，即 HIV 特异性 CD8+ T 细胞反应的新型、生物学独特的子类。
Zotero 插件