University College London, London, UK.
Curr Opin Anaesthesiol. 2012 Feb;25(1):96-101. doi: 10.1097/ACO.0b013e32834e8150.
Managing fluid balance mandates a clear identification of what goals are being sought at a particular point in the patient's pathway, an accurate assessment of both filling status and the degree of tissue hypoperfusion (if present), and a precise evaluation of response.
As no definitive data exist to show how the above targets should be optimally achieved, and with what fluid, many opinions of varied veracity currently exist. A perception from recent surveys is that critical care and intraoperative patients in Europe are more likely to receive synthetic colloid as the primary resuscitation fluid and to have cardiac output monitored by noninvasive or minimally invasive monitoring techniques. However, these preferences are based largely on tradition and local technology developments, albeit with an increasing evidence base for high-risk surgery. There is an increasing consensus that excess fluid should be avoided and that, after the initial resuscitation phase, efforts should be made to keep the patient in neutral (or perhaps negative) balance, unless clinically indicated. Likewise, the intravascular compartment should not remain underfilled if tissue hypoperfusion exists, acknowledging the above difficulties in agreeing upon definition and diagnosis.
Achieving and maintaining optimal fluid balance remains a significant challenge; better monitoring tools and definitive studies are needed.
管理液体平衡需要明确识别在患者治疗路径的特定点上所追求的目标,准确评估充盈状态和组织灌注不足的程度(如果存在),并精确评估反应。
由于没有明确的数据表明如何最佳地实现上述目标以及使用何种液体,目前存在许多真实性各不相同的观点。最近的调查显示,欧洲的重症监护和手术室内患者更有可能接受合成胶体作为主要复苏液,并使用非侵入性或微创监测技术监测心输出量。然而,这些偏好主要基于传统和当地技术的发展,尽管对于高风险手术有越来越多的证据支持。越来越多的共识认为应避免过度输液,并且在初始复苏阶段后,应努力使患者保持中性(或负性)平衡,除非临床需要。同样,如果存在组织灌注不足,血管内腔不应保持充盈不足,同时承认在定义和诊断方面存在上述困难。
实现和维持最佳液体平衡仍然是一个重大挑战;需要更好的监测工具和明确的研究。