Fried Isabella, Cerroni Lorenzo
Research Unit Dermatopathology, Department of Dermatology, Medical University of Graz, Austria.
Am J Dermatopathol. 2012 May;34(3):263-5. doi: 10.1097/DAD.0b013e31823062db.
A recent report has suggested that the numbers of regulatory T cells correlate with stage of disease and prognosis in mycosis fungoides (MF). To evaluate the role of FOXP3+ Tregs in different stages of MF, we investigated sequential biopsies in 14 patients with patch/plaque and subsequent tumor stage using FOXP3 antibody. Our data neither show a significant difference in the percentage of FOXP3+ cells between patch/plaque and tumor stage biopsies of MF nor demonstrate a predictable shift of Tregs in the course of disease progression. Additionally, we could observe FOXP3-expressing neoplastic cells in 4 patch/plaque stage biopsies, where they represented almost 100% of the epidermotropic infiltrate. Only in one of these patients, FOXP3+ cells could also be detected in the tumor stage biopsy, indicating that FOXP3 expression can be acquired or lost during the course of the disease, comparable to other phenotypic markers.
最近的一份报告表明，调节性T细胞的数量与蕈样肉芽肿（MF）的疾病分期及预后相关。为了评估FOXP3 +调节性T细胞在MF不同阶段中的作用，我们使用FOXP3抗体对14例处于斑片/斑块期及随后肿瘤期的患者进行了连续活检。我们的数据既未显示MF斑片/斑块期活检与肿瘤期活检之间FOXP3 +细胞百分比存在显著差异，也未证明在疾病进展过程中调节性T细胞有可预测的变化。此外，我们在4例斑片/斑块期活检中观察到表达FOXP3的肿瘤细胞，它们几乎占亲表皮浸润细胞的100%。仅在其中1例患者的肿瘤期活检中也检测到了FOXP3 +细胞，这表明FOXP3表达在疾病过程中可能获得或丢失，这与其他表型标志物类似。
