Head of The Children’s Obesity Clinic/The Danish Childhood Obesity Biobank, Department of Paediatrics, The University Hospital Holbæk, Smedelundsgade 60, 4300 Holbæk, Denmark.
J Hypertens. 2012 Feb;30(2):368-74. doi: 10.1097/HJH.0b013e32834e4a87.
To investigate blood pressure (BP) in relation to changes in body mass index (BMI) in obese children during weight loss and subsequent weight regain.
A longitudinal study of obese boys and girls investigated through a 12-week weight loss intervention with follow-up investigations spanning 28 months. Results shown are from baseline; day 14, 33, and 82 during weight loss; and at months 10, 16 and 28 during follow-up.
One hundred and fifteen obese children, 53 boys and 62 girls (8-15 years) with a median BMI standard deviation score (SDS) at baseline of 2.78 in boys, and 2.70 in girls. Ninety children completed the weight loss programme and 68 children entered the follow-up programme.
Height, weight, systolic blood pressure (SBP), and diastolic BP (DBP) were recorded and analysed using a general linear mixed model.
Fifty-one percent of the obese children were pre or hypertensive at baseline. Both DBP and SBP declined significantly with weight loss, but a divergent response was found in the timing of the rebound in hypertension during the weight regain phase, that is DBP increased during weight regain, whereas SBP remained lower than baseline during 28 months of continuous weight regain.
The effect of weight reduction upon obesity-associated hypertension is noticeable and suggests the importance of an intensified childhood obesity treatment strategy in order to reduce the burden of future cardiovascular disease.
研究肥胖儿童在减肥过程中及随后体重反弹期间体重指数（BMI）变化与血压（BP）的关系。
对肥胖男童和女童进行了一项为期 12 周的减肥干预的纵向研究，并进行了为期 28 个月的随访调查。本研究展示的结果来自基线；减肥期间的第 14、33 和 82 天；以及随访期间的第 10、16 和 28 个月。
115 名肥胖儿童，53 名男孩和 62 名女孩（8-15 岁），男孩的基线 BMI 标准差评分（SDS）中位数为 2.78，女孩为 2.70。90 名儿童完成了减肥计划，68 名儿童进入了随访计划。
记录身高、体重、收缩压（SBP）和舒张压（DBP），并使用一般线性混合模型进行分析。
51%的肥胖儿童在基线时已经处于高血压前期或高血压状态。随着体重减轻，DBP 和 SBP 均显著下降，但在体重恢复期间高血压反弹的时间上出现了不同的反应，即 DBP 在体重恢复期间升高，而 SBP 在持续 28 个月的体重恢复期间仍低于基线。
减肥对肥胖相关高血压的影响是显著的，这表明需要强化儿童肥胖治疗策略，以降低未来心血管疾病的负担。
