Nielsen Louise Aas, Nielsen Tenna Ruest Haarmark, Holm Jens-Christian
The Children's Obesity Clinic, Department of Paediatrics, Copenhagen University Hospital Holbx00E6;k, Holbx00E6;k, Denmark.
Obes Facts. 2015;8(5):319-28. doi: 10.1159/000441375. Epub 2015 Oct 14.
The prevalence of childhood obesity has reached alarming rates world-wide. The aetiology seems to be an interplay between genetic and environmental factors, and a surrogate measure of this complex interaction is suggested as familial predisposition. Familial predisposition to obesity and related cardiovascular disease (CVD) complications constitute the presence of obesity and/or obesity-related complications in primarily blood-related family members. The approaches of its measurement and applicability vary, and the evidence especially of its influence on obesity and obesity treatment in childhood is limited. Studies have linked a familial predisposition of obesity, CVD (hypertension, dyslipidaemia and thromboembolic events), and type 2 diabetes mellitus to BMI as well as other adiposity measures in children, suggesting degrees of familial aggregation of metabolic derangements. A pattern of predispositions arising from mothers, parents or grandparents as being most influential have been found, but further comprehensive studies are needed in order to specify the exact implications of familial predisposition. In the scope of childhood obesity this article reviews the current literature regarding familial predisposition to obesity and obesity-related complications, and how these familial predispositions may impact obesity in the offspring.
儿童肥胖症的患病率在全球已达到惊人的比例。其病因似乎是遗传因素和环境因素之间的相互作用，而家族易感性被认为是这种复杂相互作用的一个替代指标。肥胖症和相关心血管疾病（CVD）并发症的家族易感性表现为主要血亲家庭成员中存在肥胖症和/或与肥胖相关的并发症。其测量方法和适用性各不相同，尤其是其对儿童肥胖症及肥胖症治疗影响的证据有限。研究已将肥胖症、心血管疾病（高血压、血脂异常和血栓栓塞事件）以及2型糖尿病的家族易感性与儿童的体重指数（BMI）以及其他肥胖指标联系起来，表明代谢紊乱存在一定程度的家族聚集性。已发现母亲、父母或祖父母的易感性模式影响最大，但需要进一步进行全面研究以明确家族易感性的确切影响。在儿童肥胖症的范畴内，本文综述了有关肥胖症和肥胖相关并发症家族易感性的当前文献，以及这些家族易感性如何可能影响后代的肥胖情况。
