Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Curr Opin Endocrinol Diabetes Obes. 2012 Feb;19(1):13-8. doi: 10.1097/MED.0b013e32834ea723.
This review focuses on recent advances in understanding the multiple roles of gastrointestinal peptides in the control of food intake and body weight with specific emphasis on ghrelin, amylin and glucagon-like peptide 1.
Recent studies support a role for ghrelin, amylin and glucagon-like peptide 1 in short-term and long-term effects on food intake and body weight. Apart from contributing to energy homeostasis, ghrelin's participation in reward and sensory processing has been the focus of much recent work. New findings on amylin's effects on food intake and energy balance provide further support for its role in meal-related food intake and suggest that it may also function as an adiposity signal. New investigations on the role of central and peripheral glucagon-like peptide 1 receptors in mediating the anorexic effects of glucagon-like peptide 1 have suggested that they differentially contribute to short-term and long term effects on food intake.
Gastrointestinal peptides can influence food intake through mechanisms that involve short-term meal-related effects or through activation of central pathways involved in energy balance. An appreciation of the multiple actions of gastrointestinal peptides on food intake will aid in developing new strategies for weight management.
本文重点介绍了胃肠道肽在控制食物摄入和体重方面的多种作用的最新研究进展，特别关注了 ghrelin、amylin 和胰高血糖素样肽 1。
最近的研究支持 ghrelin、amylin 和胰高血糖素样肽 1 在短期和长期对食物摄入和体重的影响中的作用。除了有助于能量平衡外，ghrelin 在奖励和感觉处理中的参与一直是最近许多工作的重点。amylin 对食物摄入和能量平衡的影响的新发现为其在与进餐相关的食物摄入中的作用提供了进一步的支持，并表明它也可能作为肥胖信号发挥作用。关于中枢和外周胰高血糖素样肽 1 受体在介导胰高血糖素样肽 1 的厌食作用中的作用的新研究表明，它们对食物摄入的短期和长期影响有不同的贡献。
胃肠道肽可以通过涉及短期进餐相关效应的机制，或通过激活参与能量平衡的中枢途径来影响食物摄入。了解胃肠道肽对食物摄入的多种作用将有助于开发新的体重管理策略。
