Anderson Wesley, Barrows Mark, Lopez Fernando, Rogers Sara, Ortiz-Coffie Adriana, Norman David, Hodges Jonathan, McDonald Keith, Barnes Devon, McCall Suzanne, Don Johnson Arthur, Ceremuga Thomas E
US Army Graduate Program in Anesthesia Nursing, US Army, USA.
Holist Nurs Pract. 2012 Jan-Feb;26(1):52-7. doi: 10.1097/HNP.0b013e31823c003a.
This was a prospective, randomized, between-subjects experimental study to investigate the anxiolytic effects of naringenin, a component of mentha aquatica, and its potential interaction with the benzodiazepine binding site on the γ-aminobutyric acid (GABAA) receptor in the rat. Fifty-five rats were assigned to one of 5 groups with 11 rats per group: control, naringenin, midazolam, midazolam with naringenin, and flumazenil with naringenin. The elevated plus maze measured the behavioral components of anxiety and motor movements. Our data suggest that naringenin does not produce anxiolysis by modulation of the GABAA receptor; however, the findings indicate that naringenin decreases motor movements (P < .05).
这是一项前瞻性、随机、组间实验研究，旨在探究水生薄荷的一种成分——柚皮素的抗焦虑作用及其与大鼠γ-氨基丁酸（GABAA）受体上苯二氮䓬结合位点的潜在相互作用。55只大鼠被分为5组，每组11只：对照组、柚皮素组、咪达唑仑组、柚皮素与咪达唑仑联合组、柚皮素与氟马西尼联合组。高架十字迷宫用于测量焦虑和运动行为的组成部分。我们的数据表明，柚皮素不会通过调节GABAA受体产生抗焦虑作用；然而，研究结果表明柚皮素会减少运动行为（P < 0.05）。
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