Neonatal Intensive Care Unit, Hospital S. João, Alameda Professor Hernâni Monteiro, 4200-319 Porto, Portugal.
Eur J Dermatol. 2012 Jan-Feb;22(1):88-92. doi: 10.1684/ejd.2011.1557.
Cutaneous abnormalities in the newborn are usually benign and transitory. However, they may sometimes be extremely distressing both for parents and the medical staff, presenting with significant morbidity and mortality. The aim of this study was to access the clinical features of different skin disorders in a series of newborns, at a level III neonatal intensive care unit (NICU) in the Northern Region of Portugal, and review some of the most impressive cases. Between January 1997 and December 2010, 27 patients were found to have an important cutaneous condition that required admission to the NICU. The most frequent presentations were vesicles and pustules (n=8; 29.6%), followed by erythroderma (n=7; 25.9%), atrophic (n=5; 18.5%) and vascular lesions (n=4; 14.8%). Four (14.8%) patients died in the neonatal period, and further 4 afterwards. Genetic studies, when available, revealed three chromosomal disorders and 6 gene mutations. Overall, skin disorders were not a leading cause of NICU admission (0.43%), but were associated with significant morbidity and mortality.
新生儿的皮肤异常通常是良性且短暂的。然而，它们有时会给父母和医护人员带来极大的困扰，导致严重的发病率和死亡率。本研究旨在评估葡萄牙北部一个三级新生儿重症监护病房（NICU）中一系列新生儿不同皮肤疾病的临床特征，并回顾一些最令人印象深刻的病例。1997 年 1 月至 2010 年 12 月期间，发现 27 名患者存在需要入住 NICU 的重要皮肤状况。最常见的表现为水疱和脓疱（n=8；29.6%），其次为红皮病（n=7；25.9%）、萎缩性（n=5；18.5%）和血管病变（n=4；14.8%）。4 名（14.8%）患者在新生儿期死亡，随后又有 4 名患者死亡。有遗传研究的情况下，发现了 3 种染色体异常和 6 种基因突变。总的来说，皮肤疾病并不是 NICU 入院的主要原因（0.43%），但与较高的发病率和死亡率相关。
