School of Public Health, Department of Occupational and Environmental Health Sciences, Peking University, Beijing, China.
J Occup Environ Med. 2012 Feb;54(2):166-70. doi: 10.1097/JOM.0b013e31823d86b4.
To evaluate the correlation between chromate exposure and binucleated cells with micronuclei (BNMN) frequencies in chromate production workers and explore the ideal biomarker to detect early DNA damage.
There are 79 workers and 112 peasants in this study. Chromium concentrations in the air (CrA), blood (CrB), and urine (CrU) were detected. BNMN frequencies were also counted.
The CrA, CrB, CrU, and BNMN frequencies of the exposure group were higher than those of the control group; BNMN frequencies were positively correlated with CrB and CrU; natural logarithm (Ln) BNMN was regressed on CrB, CrU, and CrA by linear models.
The increases in CrB, CrU, and BNMN frequencies caused by lower CrA level suggest BNMN frequencies could be used to detect early DNA damage in the chromate production health surveillance.
评估铬酸盐暴露与铬酸盐生产工人双核细胞微核（BNMN）频率之间的相关性，并探讨检测早期 DNA 损伤的理想生物标志物。
本研究纳入 79 名工人和 112 名农民。检测空气中（CrA）、血液中（CrB）和尿液中（CrU）的铬浓度，并计算 BNMN 频率。
暴露组的 CrA、CrB、CrU 和 BNMN 频率均高于对照组；BNMN 频率与 CrB 和 CrU 呈正相关；通过线性模型对 CrB、CrU 和 CrA 进行自然对数（Ln）BNMN 的回归。
CrA 水平较低导致 CrB、CrU 和 BNMN 频率增加，表明 BNMN 频率可用于检测铬酸盐生产健康监测中的早期 DNA 损伤。
