Li Ping, Li Yang, Zhang Ji, Yu Shan-Fa, Wang Zhi-Liang, Jia Guang
Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing, People's Republic of China.
Shandong Center for Disease Control and Prevention, Jinan City, Shandong Province, People's Republic of China.
Toxicol Ind Health. 2016 Oct;32(10):1737-44. doi: 10.1177/0748233715580227. Epub 2015 May 5.
The concentration of chromium in the blood (CrB) has been confirmed as a biomarker for occupational chromium exposure, but its biological exposure indices (BEIs) are still unclear, so we collected data from the years 2006 and 2008 (Shandong Province, China) to analyze the relationship between the concentration of chromium in the air (CrA) of the workplaces and CrB to establish a reference value of CrB for biological monitoring of occupational workers. The levels of the indicators for nasal injury, kidney (β2 microglobulin (β2-MG)), and genetic damages (8-hydroxy-deoxyguanosine (8-OHdG) and micronucleus (MN)) were measured in all subjects of the year 2011 (Henan Province, China) to verify the protective effect in this reference value of CrB. Compared with the control groups, the concentrations of CrA and CrB in chromium exposed groups were significantly higher (P < 0.05). Positive correlations were found between CrA and CrB in chromium exposed groups (r 2006 = 0.60, r 2008 = 0.35) in the years 2006 and 2008. According to the occupational exposure limitation of CrA (50 μg/m(3), China), the reference value of CrB was recommended to 20 μg/L. The levels of nasal injury, β2-MG, 8-OhdG, and MN were not significantly different between the low chromium exposed group (CrB ≤ 20 μg/L) and the control group, while the levels of β2-MG, 8-OHdG, and MN were statistically different in the high chromium exposed group than that in the control group. This research proved that only in occupational workers, CrB could be used as a biomarker to show chromium exposure in the environment. The recommended reference value of CrB was 20 μg/L.
血液中的铬浓度（CrB）已被确认为职业性铬暴露的生物标志物，但其生物接触指数（BEIs）仍不明确，因此我们收集了2006年和2008年（中国山东省）的数据，以分析工作场所空气中的铬浓度（CrA）与CrB之间的关系，从而建立职业工人生物监测的CrB参考值。我们测量了2011年所有受试者（中国河南省）的鼻损伤、肾脏（β2微球蛋白（β2-MG））和遗传损伤（8-羟基脱氧鸟苷（8-OHdG）和微核（MN））指标水平，以验证该CrB参考值的保护作用。与对照组相比，铬暴露组的CrA和CrB浓度显著更高（P<0.05）。在2006年和2008年，铬暴露组的CrA和CrB之间存在正相关（r2006 = 0.60，r2008 = 0.35）。根据中国CrA的职业接触限值（50μg/m³），建议CrB的参考值为20μg/L。低铬暴露组（CrB≤20μg/L）和对照组之间的鼻损伤、β2-MG、8-OhdG和MN水平无显著差异，而高铬暴露组的β2-MG、8-OHdG和MN水平与对照组相比有统计学差异。本研究证明，仅在职业工人中，CrB可作为显示环境中铬暴露的生物标志物。推荐的CrB参考值为20μg/L。
