Avéret N, Coussemacq M, Cohadon F
Laboratoire de Neurochirurgie Expérimentale et Neurobiologie C.N.R.S. 040603, Université de Bordeaux II, France.
Neurochem Res. 1990 Aug;15(8):791-5. doi: 10.1007/BF00968556.
The relationship between free radicals reactions and the cell detoxifying system was investigated during the development of brain edema following a cryogenic lesion in the rabbit cerebral cortex. The amount of TBA-reactive material present six hours after freezing was less than in the controls, then increased at 48 and 96 hours. The activity of superoxide dismutase (SOD) decreased 6 hours post-injury; at the same time, we observed a stimulation of catalase activity. The glutathione peroxidase activity (GSH-Px) rose 96 hours post-lesion. The decrease of TBA-reactive products could result from an elimination rate that exceeds generation.
在兔大脑皮层低温损伤后脑水肿形成过程中，研究了自由基反应与细胞解毒系统之间的关系。冷冻后6小时，TBA反应性物质的量低于对照组，然后在48小时和96小时增加。超氧化物歧化酶（SOD）活性在损伤后6小时下降；同时，我们观察到过氧化氢酶活性受到刺激。谷胱甘肽过氧化物酶活性（GSH-Px）在损伤后96小时升高。TBA反应性产物的减少可能是由于消除速率超过生成速率所致。
