St John's Institute of Dermatology, King's College London, London, UK.
J Invest Dermatol. 2012 Jan;132(1):10-1. doi: 10.1038/jid.2011.360.
Mutations in the FLG gene, which encodes profilaggrin, are known to be a major risk factor for atopic dermatitis as well as other atopic diseases and systemic allergies. New research, however, shows that intragenic copy number variation within FLG also represents an independent risk factor for atopic dermatitis. The new findings indicate that upregulating FLG protein levels by 5-10% may have clinical utility in improving the management of many patients with dry skin and atopy.
FLG 基因编码前丝聚合蛋白，该基因突变被认为是特应性皮炎以及其他特应性疾病和全身性过敏的主要危险因素。然而，新的研究表明，FLG 基因内的基因内拷贝数变异也是特应性皮炎的一个独立危险因素。新的研究结果表明，将 FLG 蛋白水平上调 5-10%可能在改善许多患有干燥皮肤和特应性患者的管理方面具有临床应用价值。
