Fromm G H, Graff-Radford S B, Terrence C F, Sweet W H
University of Pittsburgh School of Medicine, PA 15261.
Neurology. 1990 Oct;40(10):1493-5. doi: 10.1212/wnl.40.10.1493.
Eighteen patients who subsequently developed typical trigeminal neuralgia experienced a prodromal pain termed "pre-trigeminal neuralgia." These patients described their prodromal pain as a toothache or sinusitis-like pain lasting up to several hours, sometimes triggered by jaw movements or by drinking hot or cold liquids. Typical trigeminal neuralgia developed a few days to 12 years later, and in all cases affected the same division of the trigeminal nerve. Six additional patients experiencing what appeared to be pre-trigeminal neuralgia became pain-free when taking carbamazepine or baclofen. Recognition of pretrigeminal neuralgia makes it possible to relieve the pain with appropriate medications and avoid unnecessary irreversible dental procedures.
18名随后发展为典型三叉神经痛的患者经历了一种前驱性疼痛，称为“三叉神经痛前期”。这些患者将他们的前驱性疼痛描述为牙痛或类似鼻窦炎的疼痛，持续长达数小时，有时由下颌运动或饮用热的或冷的液体引发。典型三叉神经痛在几天至12年后出现，并且在所有病例中影响三叉神经的同一分支。另外6名经历了看似三叉神经痛前期的患者在服用卡马西平或巴氯芬时疼痛消失。认识到三叉神经痛前期使得通过适当的药物缓解疼痛并避免不必要的不可逆牙科手术成为可能。
