Department of Chemistry, Sungkyunkwan University, 300 Cheoncheon, Jangan, Suwon, Gyeonggi 440-746, Korea.
Org Biomol Chem. 2012 Feb 7;10(5):1052-5. doi: 10.1039/c1ob06629c. Epub 2011 Dec 8.
Concentration-independent high enantioselectivity in the dynamic kinetic resolution (DKR) of racemic azlactones affording chiral α-aminoesters has been achieved using self-association free thiourea-based dimeric cinchona alkaloid organocatalysts. Detailed experimental studies and single crystal X-ray analysis confirmed that these bifunctional organocatalysts I do not form H-bonded self-aggregates in either solution or solid state.
在动态动力学拆分（DKR）中，使用无自缔合的硫脲基二聚奎宁生物碱手性有机催化剂，可以实现外消旋氮丙啶酮的对映选择性高且浓度独立，从而得到手性α-氨基酯。详细的实验研究和单晶 X 射线分析证实，这些双功能有机催化剂 I 在溶液或固态中均不形成氢键自聚集。
