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儿童和青少年脊柱畸形后路矫形融合术后感染。

Infections after spinal correction and fusion for spinal deformities in childhood and adolescence.

机构信息

Department of Paediatric Orthopaedics, Armand Trousseau Hospital, Pierre and Marie Curie University Paris 6, Paris, France.

出版信息

Int Orthop. 2012 Feb;36(2):465-9. doi: 10.1007/s00264-011-1439-8. Epub 2011 Dec 11.

Abstract

BACKGROUND

Infection after spinal fusion for scoliosis is a commonly reported complication. Although techniques in paediatric spinal fusion have improved with regard to infection prophylaxis, postoperative infection rates range from 0.4% to 8.7%.

INFECTION RATES AND CAUSATIVE FACTORS

The rate of infection in surgery for adolescent idiopathic scoliosis (AIS) has ranged from 0.9% to 3%. The rate of infection in spinal surgery for deformity related to myelomeningocele has been reported to be from 8% to 24%. The rate of infection in spinal surgery for deformity related to cerebral palsy has been reported to be from 6.1% to 8.7%. Infection after spinal fusion for scoliosis related to a muscular dystrophy is generally less frequent. Despite a large number of cases and studies, the literature did not provide documentation of several factors that may be related to the occurrence of wound infection. The rate of wound infection after spine surgery is dependent on many factors, including the complexity of the procedure, health status of the patient, and potentially the experience and technique of the operating surgeon.

TREATMENT ALGORITHM

The general algorithm for treatment depends on a variety of factors, including the delay from the index procedure, the infecting organism, the location and extent of the infection, the gross appearance of the fusion mass, and the surgical strategy used to correct the initial deformity. For infections that develop within the first 90 days after the index procedure all attempts to retain the instrumentation should be made. In late infections, the fusion mass must be carefully inspected before instrumentation removal is considered. Although fusion may appear to be solid both radiographically and intra-operatively, there still may be the possibility of loss of correction at last follow-up.

CONCLUSION

Deep wound infection after instrumented fusion of the spine remains a difficult and challenging clinical problem and entails substantial morbidity, cost, and recovery time for the patient. An aggressive approach to deep wound infection emphasising early irrigation and debridement allowed preservation of instrumentation and successful fusion in most cases. At the conclusion of treatment, patients can expect a medium-term clinical outcome similar to patients in whom infectious complication did not occur.

摘要

背景

脊柱融合术后感染是一种常见的并发症。尽管小儿脊柱融合技术在感染预防方面有所改进,但术后感染率仍在 0.4%至 8.7%之间。

感染率和致病因素

青少年特发性脊柱侧凸(AIS)手术的感染率为 0.9%至 3%。脊髓手术治疗与脊髓脊膜膨出相关的畸形的感染率为 8%至 24%。脊髓手术治疗与脑瘫相关的畸形的感染率为 6.1%至 8.7%。与肌肉营养不良相关的脊柱融合术后感染一般较少见。尽管有大量的病例和研究,但文献没有记录到一些可能与伤口感染有关的因素。脊柱手术后伤口感染的发生率取决于许多因素,包括手术的复杂性、患者的健康状况以及手术医生的经验和技术。

治疗方案

一般的治疗方案取决于多种因素,包括从初始手术开始的时间延迟、感染病原体、感染的位置和范围、融合块的大体外观以及用于矫正初始畸形的手术策略。对于在初始手术后 90 天内发生的感染,应尝试保留所有器械。在晚期感染中,在考虑去除器械之前,必须仔细检查融合块。尽管融合块在影像学和手术中都表现为融合,但在最后一次随访时仍有可能失去矫正。

结论

器械融合后的脊柱深部伤口感染仍然是一个困难和具有挑战性的临床问题,会给患者带来大量的发病率、成本和康复时间。积极治疗深部伤口感染,强调早期灌洗和清创,可在大多数情况下保留器械并实现成功融合。在治疗结束时,患者可以预期中期临床结果与未发生感染并发症的患者相似。

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