Venuti F S, Curatolo M, Praticò C, Orlando A, Di Giandomenico E, Maggio G, Runci D, Bellinghieri F, Montanini S
Istituto Pluridisciplinare di Anestesiologia, Rianimazione e Terapia Intensiva, Università degli Studi di Messina.
Minerva Anestesiol. 1990 Apr;56(4):113-6.
We studied 96 patients undergoing short gynecological procedures. Anaesthesia has been induced with fentanyl 1.5 micrograms/kg (45 patients) or alfentanil micrograms /kg (51 patients) and a hypnotic dose of propofol, and maintained with 70% N2O via facial mask. We observed a better and more rapid control of surgical analgesia with alfentanil, and an earlier recovery of postoperative psychophysical functions. Post-induction apnea has been more frequent and prolonged in the alfentanil group, but no difference in the time necessary to recover an adequate ventilation has been observed between the two groups. Alfentanil anaesthesia determined a more marked intraoperative bradycardia. By virtue of the speed of onset and the short duration of action, alfentanil is a suitable anaesthetic agent for short surgical procedures, particularly in day-stay patients.
我们研究了96例接受短时间妇科手术的患者。分别用1.5微克/千克芬太尼(45例患者)或阿芬太尼微克/千克(51例患者)联合催眠剂量的丙泊酚诱导麻醉,并通过面罩给予70%氧化亚氮维持麻醉。我们观察到,使用阿芬太尼时手术镇痛效果更好、起效更快,术后心理生理功能恢复更早。阿芬太尼组诱导后呼吸暂停更频繁、持续时间更长,但两组恢复充分通气所需时间无差异。阿芬太尼麻醉导致术中心动过缓更明显。由于起效迅速且作用持续时间短,阿芬太尼是短时间手术,尤其是日间手术患者合适的麻醉剂。