Northwestern University Feinberg School of Medicine, Chicago, IL 60614, USA.
Hematology Am Soc Hematol Educ Program. 2011;2011:434-9. doi: 10.1182/asheducation-2011.1.434.
Consideration of primary prophylaxis to prevent complications of sickle cell disease (SCD) requires a clear understanding of the earliest manifestations of SCD-related organ injury, a reliable clinical or laboratory tool to detect organ dysfunction, and evidence that an intervention instituted in the presymptomatic state can mitigate disease progression. This review examines the pathophysiology of SCD in organs that may be potential targets for intervention, our current capacity to evaluate early SCD manifestations, results of clinical trials, and opportunities for future interventions.
考虑到预防镰状细胞病（SCD）并发症的一级预防，需要清楚了解 SCD 相关器官损伤的最早表现，需要有可靠的临床或实验室工具来检测器官功能障碍，并且有证据表明在出现症状前的状态下进行干预可以减轻疾病进展。本文综述了可能成为干预目标的 SCD 器官的病理生理学、我们目前评估早期 SCD 表现的能力、临床试验结果以及未来干预的机会。
