镰状细胞病患儿的肾小球滤过率发生改变：Hb SS与Hb SC的比较。
Glomerular filtration rate is altered in children with sickle cell disease: a comparison between Hb SS and Hb SC.
作者信息
de Paula Rafael Pereira, Nascimento Alana Ferreira, Sousa Sandra Mara Bispo, Bastos Paulo Roberto Velasco, Barbosa Ana Angélica Leal
机构信息
Universidade Estadual do Sudoeste da Bahia - UESB, Jequié, BA, Brazil.
出版信息
Rev Bras Hematol Hemoter. 2013;35(5):349-51. doi: 10.5581/1516-8484.20130107.
BACKGROUND
Renal failure is common among older patients with sickle cell disease; this is preceded by subclinical glomerular hyperfiltration. Data about renal function of adults with sickle cell disease have been reported, but data on children is scarce, especially when comparing heterozygotic and homozygotic patients.
OBJECTIVE
The goal of this study was to investigate the glomerular filtration rate of heterozygotic and homozygotic children with sickle cell disease.
METHODS
The glomerular filtration rate of 11 children with sickle cell disease [7 homozygotic (SS) and 4 heterozygotic (SC)] with a mean age of 11 years (standard deviation: ± 5 years) was evaluated using standard laboratory techniques. Results are presented as descriptive analysis.
RESULTS
Our results suggest that glomerular hyperfiltration is present in children with sickle cell disease; this is more evident in homozygotic than heterozygotic children.
CONCLUSION
There is evidence of a need to monitor the renal function of children with sickle cell disease when special attention should be paid to homozygotic patients.
背景
肾衰竭在老年镰状细胞病患者中很常见；在此之前会出现亚临床肾小球高滤过。已有关于成年镰状细胞病患者肾功能的数据报道，但关于儿童的数据很少，尤其是在比较杂合子和纯合子患者时。
目的
本研究的目的是调查镰状细胞病杂合子和纯合子儿童的肾小球滤过率。
方法
采用标准实验室技术评估了11名平均年龄为11岁（标准差：±5岁）的镰状细胞病儿童[7名纯合子（SS）和4名杂合子（SC）]的肾小球滤过率。结果以描述性分析呈现。
结果
我们的结果表明，镰状细胞病儿童存在肾小球高滤过；这在纯合子儿童中比杂合子儿童更明显。
结论
有证据表明需要监测镰状细胞病儿童的肾功能，此时应特别关注纯合子患者。
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