Department of Clinical Medicine, Section of Experimental and Clinical Pharmacology, University of Insubria, Via Ottorino Rossi n. 9, 21100 Varese, VA, Italy.
Amino Acids. 2013 Jul;45(1):55-71. doi: 10.1007/s00726-011-1186-6. Epub 2011 Dec 8.
Sympathoadrenergic pathways are crucial to the communication between the nervous system and the immune system. The present review addresses emerging issues in the adrenergic modulation of immune cells, including: the specific pattern of adrenoceptor expression on immune cells and their role and changes upon cell differentiation and activation; the production and utilization of noradrenaline and adrenaline by immune cells themselves; the dysregulation of adrenergic immune mechanisms in disease and their potential as novel therapeutic targets. A wide array of sympathoadrenergic therapeutics is currently used for non-immune indications, and could represent an attractive source of non-conventional immunomodulating agents.
交感神经系统途径对于神经系统和免疫系统之间的通讯至关重要。本综述讨论了免疫细胞的肾上腺素能调节中出现的新问题，包括：免疫细胞上肾上腺素能受体表达的特定模式及其在细胞分化和激活过程中的作用和变化；免疫细胞自身产生和利用去甲肾上腺素和肾上腺素；疾病中肾上腺素能免疫机制的失调及其作为新型治疗靶点的潜力。目前，有大量的拟交感神经治疗药物用于非免疫适应症，它们可能是一种有吸引力的非传统免疫调节剂来源。
