Murphy Rachel A, Bureyko Taylor F, Mourtzakis Marina, Chu Quincy S, Clandinin M Thomas, Reiman Tony, Mazurak Vera C
Department of Agricultural, Food and Nutritional Science, University of Alberta, 4-126A Li Ka Shing Centre, Edmonton, AB T6G 2E1, Canada.
Lipids. 2012 Apr;47(4):363-9. doi: 10.1007/s11745-011-3641-2. Epub 2011 Dec 10.
Abnormalities in lipid metabolism have been frequently observed in cancer and are associated with a poor prognosis. However, a detailed, longitudinal characterization of fatty acid status is lacking. This study aimed to assess plasma phospholipid fatty acids before chemotherapy, immediately after and 1 month following chemotherapy in a group of 50 patients newly diagnosed with lung cancer and explore factors which may contribute to aberrations in fatty acids. Their mean ± SD characteristics: age 64 ± 8.5 years, 75% advanced stage disease, body mass index 27.0 ± 5.4 kg/m², 6 month weight loss -4.6 ± 6.1%. Compared to patients with early stage disease, patients with advanced disease had abnormal fatty acid profiles including significantly lower (P < 0.05) amounts of total phospholipid fatty acids, saturated, and polyunsaturated fatty acids (linoleic, arachidonic, eicosapentaenoic and docosahexaenoic). Longitudinal analysis revealed that patients with advanced disease who completed chemotherapy had stable fatty acid levels and continued to maintain levels 1 month following completion of chemotherapy. Comparatively, patients who did not complete chemotherapy due to toxicity or disease progression had progressive loss of total phospholipid fatty acids, stearic, linoleic and n-6 fatty acids and a trend towards lower docosahexaenoic, arachidonic, palmitic, n-3 and saturated fatty acids. These results suggest that loss of fatty acids is prevalent, progressive and potentially influenced by advanced disease and chemotherapy treatment.
脂质代谢异常在癌症中经常被观察到，并且与预后不良相关。然而，缺乏对脂肪酸状态的详细纵向特征描述。本研究旨在评估50例新诊断肺癌患者化疗前、化疗后即刻及化疗后1个月时的血浆磷脂脂肪酸，并探讨可能导致脂肪酸异常的因素。他们的平均±标准差特征如下：年龄64±8.5岁，75%为晚期疾病，体重指数27.0±5.4kg/m²，6个月体重减轻-4.6±6.1%。与早期疾病患者相比，晚期疾病患者的脂肪酸谱异常，包括总磷脂脂肪酸、饱和脂肪酸和多不饱和脂肪酸（亚油酸、花生四烯酸、二十碳五烯酸和二十二碳六烯酸）的含量显著降低（P<0.05）。纵向分析显示，完成化疗的晚期疾病患者脂肪酸水平稳定，化疗完成后1个月仍维持该水平。相比之下，因毒性或疾病进展未完成化疗的患者，总磷脂脂肪酸、硬脂酸、亚油酸和n-6脂肪酸逐渐减少，二十二碳六烯酸、花生四烯酸、棕榈酸、n-3脂肪酸和饱和脂肪酸有降低趋势。这些结果表明，脂肪酸的流失普遍存在、呈进行性，并且可能受晚期疾病和化疗的影响。
