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Frontocingulate dysfunction in depression: toward biomarkers of treatment response.抑郁患者额眶部皮质功能障碍：寻找治疗反应的生物标志物。
Neuropsychopharmacology. 2011 Jan;36(1):183-206. doi: 10.1038/npp.2010.166. Epub 2010 Sep 22.
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Vasopressin modulates medial prefrontal cortex-amygdala circuitry during emotion processing in humans.加压素调节人类情绪处理过程中前额皮质内侧-杏仁核回路。
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Amygdala reactivity is inversely related to level of cannabis use in individuals with comorbid cannabis dependence and major depression.杏仁核反应性与同时患有大麻依赖和重度抑郁症个体的大麻使用水平呈负相关。
Addict Behav. 2010 Jun;35(6):644-6. doi: 10.1016/j.addbeh.2010.02.004. Epub 2010 Feb 10.
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CB1 receptor deficiency decreases wheel-running activity: consequences on emotional behaviours and hippocampal neurogenesis.大麻素受体 1 缺失可减少转轮运动活动：对情绪行为和海马神经发生的影响。
Exp Neurol. 2010 Jul;224(1):106-13. doi: 10.1016/j.expneurol.2010.01.017. Epub 2010 Feb 4.
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Opposite effects of delta-9-tetrahydrocannabinol and cannabidiol on human brain function and psychopathology.大麻二酚和Δ9-四氢大麻酚对人脑功能和精神病理学的相反影响。
Neuropsychopharmacology. 2010 Feb;35(3):764-74. doi: 10.1038/npp.2009.184. Epub 2009 Nov 18.
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The endocannabinoid system and the treatment of mood and anxiety disorders.内源性大麻素系统与心境和焦虑障碍的治疗。
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Modulation of effective connectivity during emotional processing by Delta 9-tetrahydrocannabinol and cannabidiol.Delta 9-四氢大麻酚和大麻二酚对情绪加工过程中有效连接的调制。
Int J Neuropsychopharmacol. 2010 May;13(4):421-32. doi: 10.1017/S1461145709990617. Epub 2009 Sep 24.
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Altered affective response in marijuana smokers: an FMRI study.大麻吸食者情感反应的改变：一项功能磁共振成像研究。
Drug Alcohol Depend. 2009 Nov 1;105(1-2):139-53. doi: 10.1016/j.drugalcdep.2009.06.019. Epub 2009 Aug 4.
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The endocannabinoid system as a target for novel anxiolytic and antidepressant drugs.内源性大麻素系统作为新型抗焦虑和抗抑郁药物的靶点。
Int Rev Neurobiol. 2009;85:57-72. doi: 10.1016/S0074-7742(09)85005-8.
10
Distinct effects of {delta}9-tetrahydrocannabinol and cannabidiol on neural activation during emotional processing.Δ9-四氢大麻酚和大麻二酚对情绪加工过程中神经激活的不同影响。
Arch Gen Psychiatry. 2009 Jan;66(1):95-105. doi: 10.1001/archgenpsychiatry.2008.519.

大麻素对负性情绪体验期间扣带回前皮质下激活的调制作用。

Cannabinoid modulation of subgenual anterior cingulate cortex activation during experience of negative affect.

机构信息

Department of Psychiatry, University of Michigan, Rachel Upjohn Building, 4250 Plymouth Road, Box 5765, Ann Arbor, MI 48109-2700, USA.

出版信息

J Neural Transm (Vienna). 2012 Jun;119(6):701-7. doi: 10.1007/s00702-011-0747-x. Epub 2011 Dec 11.

DOI:10.1007/s00702-011-0747-x
PMID:22160489
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4242592/
Abstract

Cannabinoids affect positive and negative affective experience and emotional perception, possibly by modulating limbic brain reactivity. In this double-blind crossover, placebo-controlled functional magnetic resonance imaging study in humans, an acute oral dose of ∆(9)-tetrahydrocannabinol (THC) attenuated subgenual anterior cingulate cortex (sgACC) reactivity during the induction of negative affect. This observation extends prior findings implicating a cortico-limbic, emotion-related central mechanism underlying cannabinoid function.

摘要

大麻素影响积极和消极的情感体验和情绪感知，可能通过调节边缘脑反应来实现。在这项人类双盲交叉安慰剂对照功能磁共振成像研究中，急性口服 ∆(9)-四氢大麻酚 (THC) 可减弱诱导负性情绪时的扣带前回下部 (sgACC) 反应。这一观察结果扩展了先前的发现，表明大麻素功能的核心机制涉及皮质-边缘，与情绪相关的中枢机制。