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钙调素:一种特异性结合钙的线粒体蛋白,存在于快肌纤维中。

Calmitine: a calcium-binding mitochondrial protein specific for fast-twitch muscle fibers.

作者信息

Lucas-Heron B, Schmitt N, Ollivier B

机构信息

Laboratoire de Physiologie--U.E.R. de Médecine, Nantes, France.

出版信息

Neurosci Lett. 1990 Jul 17;115(1):103-7. doi: 10.1016/0304-3940(90)90525-e.

DOI:10.1016/0304-3940(90)90525-e
PMID:2216052
Abstract

Mitochondrial fractions were isolated from fast-twitch (EDL), slow-twitch (soleus) and heart muscle of normal rat (WKY). Protein separation by electrophoresis and study of calcium-45 binding showed that a specific calcium protein (designated as calmitine) was present in the mitochondria of fast-twitch muscle but practically inexistent in slow-twitch and cardiac muscle. It seems to be related to calcium uptake by an energy-dependent mechanism.

摘要

从正常大鼠(WKY)的快肌(趾长伸肌)、慢肌(比目鱼肌)和心肌中分离出线粒体部分。通过电泳进行蛋白质分离并研究钙-45结合情况,结果表明一种特定的钙蛋白(命名为钙调节素)存在于快肌的线粒体中,但在慢肌和心肌中几乎不存在。它似乎与通过能量依赖机制摄取钙有关。

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Calmitine: a calcium-binding mitochondrial protein specific for fast-twitch muscle fibers.钙调素:一种特异性结合钙的线粒体蛋白,存在于快肌纤维中。
Neurosci Lett. 1990 Jul 17;115(1):103-7. doi: 10.1016/0304-3940(90)90525-e.
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引用本文的文献

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Understanding dystrophinopathies: an inventory of the structural and functional consequences of the absence of dystrophin in muscles of the mdx mouse.理解肌营养不良症:mdx小鼠肌肉中肌营养不良蛋白缺失的结构和功能后果综述
J Muscle Res Cell Motil. 1999 Oct;20(7):605-25. doi: 10.1023/a:1005545325254.
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Muscle regeneration and mitochondrial calmitine increase in the dystrophic dy/dy mouse after intramuscular chlorpromazine injection.
肌肉注射氯丙嗪后,营养不良性dy/dy小鼠的肌肉再生及线粒体肉碱增加。
Acta Neuropathol. 1995;90(3):299-304. doi: 10.1007/BF00296514.