Lucas-Heron B, Louboutin J P, Ollivier B, Schmitt N
Groupe de Recherche sur les Myopathies, U.E.R. de Médecine, Nantes, France.
Acta Neuropathol. 1995;90(3):299-304. doi: 10.1007/BF00296514.
We studied the effect of chlorpromazine injection on the gastrocnemius muscles of C57BL/6J dy/dy dystrophic mice. Changes in mitochondrial calmitine concentrations and differences in microscopy studies, fibre typing and morphometry were compared in gastrocnemius muscles of dystrophic and control mice before and 2 and 21 days after injection. In both cases, calmitine reduction associated with muscle degeneration was observed 2 days after drug injection. Calmitine then increased, reaching a level at day 21 nearly identical to that of controls before injection. This increase was associated with muscle regeneration. These results clearly indicate that dystrophic mouse muscle can regenerate calmitine after drug-induced damage.
我们研究了氯丙嗪注射对C57BL/6J dy/dy营养不良小鼠腓肠肌的影响。比较了营养不良小鼠和对照小鼠在注射前、注射后2天和21天腓肠肌中线粒体钙调蛋白浓度的变化以及显微镜研究、纤维类型和形态测量的差异。在两种情况下，药物注射后2天均观察到与肌肉变性相关的钙调蛋白减少。然后钙调蛋白增加，在第21天达到几乎与注射前对照相同的水平。这种增加与肌肉再生有关。这些结果清楚地表明，营养不良小鼠的肌肉在药物诱导损伤后可以再生钙调蛋白。
