School of Electrical Engineering, Korea University, #207 Engineering Bldg., Anamdong, Seongbukgu, Seoul 136-713, Korea.
Arch Virol. 2012 Mar;157(3):497-501. doi: 10.1007/s00705-011-1181-y. Epub 2011 Dec 8.
Some viruses have been reported to transcribe microRNAs, implying complex relationships between the host and the pathogen at the post-transcriptional level through microRNAs in virus-infected cells. Although many computational algorithms have been developed for microRNA target prediction, few have been designed exclusively to find cellular or viral mRNA targets of viral microRNAs in a user-friendly manner. To address this, we introduce the viral microRNA host target (vHoT) database for predicting interspecies interactions between viral microRNA and host genomes. vHoT supports target prediction of 271 viral microRNAs from human, mouse, rat, rhesus monkey, cow, and virus genomes. vHoT is freely available at http://dna.korea.ac.kr/vhot.
有些病毒已被报道能够转录 microRNAs，这意味着病毒感染细胞中的 microRNAs 在转录后水平上通过 microRNAs 暗示了宿主和病原体之间的复杂关系。尽管已经开发了许多用于 microRNA 靶标预测的计算算法，但很少有专门用于以用户友好的方式发现病毒 microRNA 的细胞或病毒 mRNA 靶标的算法。为了解决这个问题，我们引入了病毒 microRNA 宿主靶标 (vHoT) 数据库，用于预测病毒 microRNA 和宿主基因组之间的种间相互作用。vHoT 支持来自人类、小鼠、大鼠、恒河猴、牛和病毒基因组的 271 种病毒 microRNA 的靶标预测。vHoT 可在 http://dna.korea.ac.kr/vhot 免费获取。
