The Biomedical Center, 8, Vyborgskaya St., St. Petersburg, 194044, Russia.
Eur J Clin Microbiol Infect Dis. 2012 Aug;31(8):1753-7. doi: 10.1007/s10096-011-1497-2. Epub 2011 Dec 8.
Molecular epidemiological features of Mycobacterium tuberculosis strains among different patient groups in Russia have not been studied well. The aim of our study was to compare the genotypes of M. tuberculosis strains circulating among tuberculosis (TB) patients from different groups: homeless, human immunodeficiency virus (HIV)-infected, prisoners, and the general population of St. Petersburg citizens. One hundred and forty-two M. tuberculosis complex isolates from different TB patient groups were studied using the spacer oligonucleotide typing (spoligotyping) method. The majority of the studied M. tuberculosis isolates in all groups belonged to the Beijing family (55% among homeless; 77% among HIV-infected; 60% among the general population; 81% among prisoners). There were no significant differences in the Beijing family prevalence among homeless patients, HIV/TB co-infected patients, and the general population of TB patients. The lowest genetic diversity of the pathogen was detected among imprisoned patients. The results of our study demonstrate that M. tuberculosis strains circulating among patients from high-risk groups are also spread among the general population of St. Petersburg citizens.
俄罗斯不同患者群体中的结核分枝杆菌菌株的分子流行病学特征尚未得到很好的研究。本研究的目的是比较来自不同患者群体（无家可归者、人类免疫缺陷病毒（HIV）感染者、囚犯和圣彼得堡市民普通人群）的肺结核（TB）患者中流行的结核分枝杆菌菌株的基因型。使用间隔寡核苷酸分型（ spoligotyping ）方法研究了来自不同 TB 患者群体的 142 株结核分枝杆菌复合体分离株。在所研究的所有组中的大多数结核分枝杆菌分离株属于北京家族（无家可归者中占 55%；HIV 感染者中占 77%；普通人群中占 60%；囚犯中占 81%）。无家可归者、HIV/TB 合并感染患者和普通人群 TB 患者之间北京家族的流行率没有显著差异。在被监禁的患者中检测到病原体的遗传多样性最低。我们的研究结果表明，在高危人群中的患者中流行的结核分枝杆菌菌株也在圣彼得堡市民的普通人群中传播。
