Center for Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 65 Landsdowne Street, Cambridge, MA 02139, USA.
Small. 2012 Feb 6;8(3):393-403. doi: 10.1002/smll.201101745. Epub 2011 Dec 9.
A simple technique is presented for controlling the shapes of micro- and nanodrops by patterning surfaces with special hydrophilic regions surrounded by hydrophobic boundaries. Finite element method simulations link the shape of the hydrophilic regions to that of the droplets. Shaped droplets are used to controllably pattern planar surfaces and microwell arrays with microparticles and cells at the micro- and macroscales. Droplets containing suspended sedimenting particles, initially at uniform concentration, deposit more particles under deeper regions than under shallow regions. The resulting surface concentration is thus proportional to the local fluid depth and agrees well with the measured and simulated droplet profiles. A second application is also highlighted in which shaped droplets of prepolymer solution are crosslinked to synthesize microgels with tailored 3D geometry.
本文提出了一种简单的技术，通过图案化具有特殊亲水区和疏水边界的表面来控制微纳米液滴的形状。有限元方法模拟将亲水区的形状与液滴的形状联系起来。通过使用成型液滴，可以在微尺度和宏观尺度上对平面表面和微井阵列进行可控图案化，将微粒子和细胞沉积在表面上。含有悬浮沉降颗粒的液滴，初始浓度均匀，在较深区域比在较浅区域沉积更多的颗粒。因此，得到的表面浓度与局部流体深度成正比，与测量和模拟的液滴轮廓吻合较好。本文还强调了另一个应用，即通过交联预聚物溶液的成型液滴来合成具有定制 3D 几何形状的微凝胶。
