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苯佐卡因喷雾剂所致高铁血红蛋白血症的非典型表现。

Atypical presentations of methemoglobinemia from benzocaine spray.

作者信息

Tantisattamo Ekamol, Suwantarat Nuntra, Vierra Joseph R, Evans Samuel J

机构信息

Department of Medicine, John A. Burns School of Medicine, University of Hawai'i, Honolulu, 96813, USA.

出版信息

Hawaii Med J. 2011 Jun;70(6):125-6.

PMID:22162610
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3233396/
Abstract

Widely used for local anesthesia, especially prior to endoscopic procedures, benzocaine spray is one of the most common causes of iatrogenic methemoglobinemia. The authors report an atypical case of methemoglobinemia in a woman presenting with pale skin and severe hypoxemia, after a delayed repeat exposure to benzocaine spray. Early recognition and prompt management of methemoglobinemia is needed in order to lessen morbidity and mortality from this entity.

摘要

苯佐卡因喷雾剂广泛用于局部麻醉,尤其是在内镜检查之前,它是医源性高铁血红蛋白血症最常见的病因之一。作者报告了一例非典型高铁血红蛋白血症病例,该病例为一名女性,在延迟重复接触苯佐卡因喷雾剂后,出现皮肤苍白和严重低氧血症。为了降低该病症的发病率和死亡率,需要对高铁血红蛋白血症进行早期识别和及时处理。

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本文引用的文献

1
Methemoglobinemia related to local anesthetics: a summary of 242 episodes.与局部麻醉药相关的高铁血红蛋白血症:242例病例总结
Anesth Analg. 2009 Mar;108(3):837-45. doi: 10.1213/ane.0b013e318187c4b1.
2
Topical benzocaine-induced methemoglobinemia in the pediatric population.局部应用苯佐卡因引起的小儿高铁血红蛋白血症。
J Pediatr Health Care. 2008 Nov-Dec;22(6):335-9; quiz 340-1. doi: 10.1016/j.pedhc.2008.08.008.
3
Severe methemoglobinemia from topical benzocaine 7.5% (baby orajel) use for teething pain in a toddler.一名幼儿因使用7.5%的外用苯佐卡因(婴儿牙痛凝胶)缓解出牙疼痛而导致严重高铁血红蛋白血症。
Clin Pediatr (Phila). 2009 Mar;48(2):209-11. doi: 10.1177/0009922808324491. Epub 2008 Oct 3.
4
Intraoperative detection of methemoglobinemia in a patient given benzocaine spray to relieve discomfort from a nasogastric tube: a case report.术中检测到一名使用苯佐卡因喷雾剂缓解鼻胃管不适的患者出现高铁血红蛋白血症:病例报告
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CJEM. 2001 Jan;3(1):51-6. doi: 10.1017/s1481803500005182.
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Acquired methemoglobinemia: a retrospective series of 138 cases at 2 teaching hospitals.获得性高铁血红蛋白血症:两家教学医院138例回顾性研究系列病例
Medicine (Baltimore). 2004 Sep;83(5):265-273. doi: 10.1097/01.md.0000141096.00377.3f.
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Methemoglobinemia induced by topical anesthesia: a case report and review.局部麻醉引起的高铁血红蛋白血症:一例报告及文献复习
Am J Med Sci. 1999 Dec;318(6):415-8. doi: 10.1097/00000441-199912000-00009.
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Methemoglobinemia: etiology, pharmacology, and clinical management.高铁血红蛋白血症:病因、药理学及临床管理
Ann Emerg Med. 1999 Nov;34(5):646-56. doi: 10.1016/s0196-0644(99)70167-8.
9
Suspected severe methemoglobinemia caused by topical application of an ointment containing benzocaine around the enterostomy.怀疑因在肠造口周围局部应用含苯佐卡因的药膏而导致严重高铁血红蛋白血症。
Anesth Analg. 1999 May;88(5):1190-1. doi: 10.1097/00000539-199905000-00051.
10
Methemoglobinemia from perineal application of an anesthetic cream.会阴部涂抹麻醉乳膏导致的高铁血红蛋白血症。
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